Spatial Memory Deficit and Tau Hyperphosphorylation Induced by Inhibiting PP2A in Rat Brain  

作　　者：TIAN Qing ZHENG Hong-yun CHEN Juan Hong-lian GONG Cheng-xin WANG Jian-zhi 

机构地区：[1]Pathophysiology Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China [2]Medical College, Huangshi College of Technology, Huangshi 435003, Hubei,China [3]The New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA

出　　处：《Wuhan University Journal of Natural Sciences》2005年第6期1030-1034,共5页武汉大学学报（自然科学英文版）

基　　金：Supported by the National Natural Science Foundation of China(30370560 ,39925012 ,30100057 ,30170221) and a Grant fromthe Li Founda-tion, USA

摘　　要：Hyperphosphorylation of Tau in Alzheimer＇s disease （AD） brain appears to be caused by a down-regulation of protein phospbatase 2A （PP2A）. In this study, we selectively inhibited PP2A by injection of okadaic acid （OA） into the Meynert nucleus basalis of rats and found that 0.4 pmol of OA injeetion induced approximately 60% inhibition of PP2A 24 h after injection, 13% inhibition 48 h after injection and no obvious inhibition 72 h after injection. Hyperphosphorylation of Tau at Ser-198/ Ser-199/Ser-202 and Ser-396/Ser-404 and spatial memory deficit of rats were induced 24 h after 0. d prnol of OA injection. This study suggests that a dowreregulation of PP2A may underlie almormal hyperphosphorylation of cytoskeletal proteins leading to neurofibrillary degeneration in AD.Hyperphosphorylation of Tau in Alzheimer＇s disease （AD） brain appears to be caused by a down-regulation of protein phospbatase 2A （PP2A）. In this study, we selectively inhibited PP2A by injection of okadaic acid （OA） into the Meynert nucleus basalis of rats and found that 0.4 pmol of OA injeetion induced approximately 60% inhibition of PP2A 24 h after injection, 13% inhibition 48 h after injection and no obvious inhibition 72 h after injection. Hyperphosphorylation of Tau at Ser-198/ Ser-199/Ser-202 and Ser-396/Ser-404 and spatial memory deficit of rats were induced 24 h after 0. d prnol of OA injection. This study suggests that a dowreregulation of PP2A may underlie almormal hyperphosphorylation of cytoskeletal proteins leading to neurofibrillary degeneration in AD.

关 键 词：protein phosphatase 2A TAU Alzheimer＇s disease 

分 类 号：R-332[医药卫生]