Slit-Robo信号在涎腺腺样囊性癌嗜神经侵袭中的表达和意义  

Expression and significance of Slit/Robo signal in salivary adenoid cystic carcinoma

作　　者：贾江[1] 刘兰忠[1] 钱震[1] 韩冰[2] 刘冠花[1] 王丽京[2] 

机构地区：[1]兰州军区兰州总医院口腔科,甘肃兰州730050 [2]兰州大学口腔医院

出　　处：《西北国防医学杂志》2005年第6期416-418,F0002,共4页Medical Journal of National Defending Forces in Northwest China

基　　金：国家自然科学基金资助项目(30470858)

摘　　要：目的:了解涎腺腺样囊性癌(SACC)中Slit蛋白和其受体Robo的表达并探讨其在肿瘤嗜神经侵袭中的意义。方法:对34例SACC进行组织分型、嗜神经性分组,同时应用免疫组化方法,对SACC中Slit/Robo的表达进行检测。结果:有嗜神经现象、临床复发的SACC病例中Slit/Robo的表达较无嗜神经现象、临床无复发的病例显著升高(P<0.05)。结论:Slit/Robo在不同分组SACC中均存在不同程度的阳性表达。Slit/Robo与SACC的嗜神经性、临床复发具有密切关系。Objective： To investigate the expression of Slit protein and its receptor Robo protein in human salivary adenoid cystic carcinoma （SACC） and their effects in neural invasive ability. Methods： According to tissue types and neural invasive ability of SACC, the expression of Slit and Robo proteins were detected with immunohistochemical assay from 34 cases. Results： The expression of Slit and Robo proteins in the cases of neurotropism and recurrence significantly increased as compared with that in the cases of non - neural invasion and non - recurrence, （P 〈 0.05）. Conclusion： These results suggested that Slit and Robo proteins were expressed in SACC. Slit and Robo proteins may have relations with neurotropism and recurrence of SACC.

关 键 词：涎腺腺样囊性癌 SLIT ROBO 嗜神经性 

分 类 号：R739.8[医药卫生—肿瘤]