Two ligands for a GPCR,proton vs lysolipid  

作　　者：Dong-soon IM 

机构地区：[1]Laboratory of Pharmacology and Research Institute of Drug Development,College of Pharmacy,Pusan National University Busan 609-735,Republic of Korea

出　　处：《Acta Pharmacologica Sinica》2005年第12期1435-1441,共7页中国药理学报（英文版）

基　　金：Project supported by the Korea Science and Engineering Foundation Grant(R01-2005-000-10011-02005).

摘　　要：Aim：Recently, two different chemicals have been matched as ligands with the same Gprotein-coupled receptor （GPCR）. Double-pairing of OGR 1 family GPCRs with proton and lysolipid raises several questions. First, whether both are the real ligands for the GPCRs. Second, whether modulation of a GPCR by two chemicals could be possible. Third, one of the chemicals is proton. Proton-sensing not only is a new action mode of GPCR activation, but also it could be generalized in other GPCRs. In this review, I＇d like to summarize the issue and discuss questions with pharmacological criteria.Aim：Recently, two different chemicals have been matched as ligands with the same Gprotein-coupled receptor （GPCR）. Double-pairing of OGR 1 family GPCRs with proton and lysolipid raises several questions. First, whether both are the real ligands for the GPCRs. Second, whether modulation of a GPCR by two chemicals could be possible. Third, one of the chemicals is proton. Proton-sensing not only is a new action mode of GPCR activation, but also it could be generalized in other GPCRs. In this review, I＇d like to summarize the issue and discuss questions with pharmacological criteria.

关 键 词：lysolipid PROTON G-protein-coupled receptor SPHINGOSYLPHOSPHORYLCHOLINE LYSOPHOSPHATIDYLCHOLINE PSYCHOSINE 

分 类 号：R91[医药卫生—药学]