SPHINGOSYLPHOSPHORYLCHOLINE

作品数：6被引量：10H指数：2
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相关领域：医药卫生生物学更多>>
相关期刊：《Chinese Medical Journal》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金更多>>
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Sphingosylphosphorylcholine alleviates pressure overload-induced myocardial remodeling in mice via inhibiting CaM-JNK/p38 signaling pathway
《Acta Pharmacologica Sinica》2024年第2期312-326,共15页Fang-fang Ren Lin Zhao Xian-yun Jiang Jing-jing Zhang Jia-min Gou Xiao-yu Yu Shu-jin Wu Lei Li 
supported by Grant No.LZ23H020001 from the Key Natural Science Foundation of Zhejiang Province and Xinmiao Talent Program of Zhejiang Province(Grant No.2023R413084).
Apoptosis plays a critical role in the development of heart failure,and sphingosylphosphorylcholine(SPC)is a bioactive sphingolipid naturally occurring in blood plasma.Some studies have shown that SPC inhibits hypoxia...
关键词：heart failure pressure overload cardiac hypertrophy cardiac fibrosis apoptosis CARDIOMYOCYTE 
Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases被引量：1
《Acta Pharmacologica Sinica》2018年第12期1830-1836,共7页Di Ge Hong-wei Yue Hong-hong Liu Jing Zhao 
Sphingosylphosphorylcholine (SPC) is a bioactive sphingolipid in blood plasma that is metabolized from the hydrolysis of the membrane sphingolipid. SPC maintains low levels in the circulation under normal conditions, ...
关键词：SPHINGOSYLPHOSPHORYLCHOLINE SPHINGOLIPID second MESSENGER first MESSENGER G protein-coupled receptor membrane lipid raft MYOCYTES VEIN endothelial cell vascular smooth muscle cells 
Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn被引量：2
《Acta Pharmacologica Sinica》2012年第1期57-65,共9页
Aim： In vascular strips, the adjacent endothelial cells modulate the contraction of vascular smooth muscle cells （VSMCs） induced by sphingosylphosphorylcholine （SPC） through nitric oxide （NO）. The aim of this s...
关键词：human umbilical vein vascular endothelial cells vascular smooth muscle cells integrin β4 FYN CONTRACTION sphingosylphosphorylcholine Keywords： human umbilical vein vascular endothelial cells vascular smooth muscle cells integrin 134 FYN CONTRACTION SPHINGOSYLPHOSPHORYLCHOLINE 
Effects of ovarian cancer G protein coupled receptor 1 on the proliferation, migration, and adhesion of human ovarian cancer cells被引量：5
《Chinese Medical Journal》2011年第9期1327-1332,共6页REN Juan ZHANG Long 
This research was supported by the grants from the National Natural Science Foundation of China （No. 30973175）, Scientific Research Foundation for Returning Scholars of Education Ministry of China （No. 0601-18920006）, Scientific and Technological Research Foundation of Shaanxi Province （No. 2007K09-09）, and the Clinical Research Fundation of First Hospital of Xi＇an Jiaotong University of China.
Background OGR1 was found as a G-protein coupled receptor （GPCR） and proton sensor. Our previous studies have found that OGR1 has inhibitory effect on the metastasis of prostate cancer. In order to investigate the r...
关键词：ovarian cancer g protein coupled receptor 1 ovarian cancer tumor metastasis SPHINGOSYLPHOSPHORYLCHOLINE LYSOPHOSPHATIDYLCHOLINE 
Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis
《Acta Pharmacologica Sinica》2006年第10期1359-1366,共8页Ha-young LEE Eun-ha SHIN Yoe-sik BAE 
Aim： To investigate the effects of sphingosylphosphorylcholine （SPC） on human monocyte-derived dendritic cell （DC） chemotaxis. Methods： Human DC were generated from peripheral blood monocytes by culturing them w...
关键词：dendritic cells sphingosylphosphorylcho line CHEMOTAXIS pertussis toxin-sensitive G protein extracellular signal regulated protein kinase 
Two ligands for a GPCR,proton vs lysolipid被引量：2
《Acta Pharmacologica Sinica》2005年第12期1435-1441,共7页Dong-soon IM 
Project supported by the Korea Science and Engineering Foundation Grant(R01-2005-000-10011-02005).
Aim：Recently, two different chemicals have been matched as ligands with the same Gprotein-coupled receptor （GPCR）. Double-pairing of OGR 1 family GPCRs with proton and lysolipid raises several questions. First, whe...
关键词：lysolipid PROTON G-protein-coupled receptor SPHINGOSYLPHOSPHORYLCHOLINE LYSOPHOSPHATIDYLCHOLINE PSYCHOSINE 
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