杂色曲霉素对小鼠穹窿下器室管膜细胞超微结构的影响  

Effects of sterigmatocystin on ultrastructure of ependemal cells of subfornical organ in mice

作　　者：郝庆卯[1] 张祥宏[1] 邢凌霄[1] 王俊灵[1] 严霞[1] 马常升[1] 王丽[1] 刘贵生[1] 王凤荣[1] 杨天祝[1] 

机构地区：[1]河北医科大学病理研究室,石家庄050017

出　　处：《解剖学杂志》2005年第6期650-652,共3页Chinese Journal of Anatomy

摘　　要：目的:观察杂色曲霉素(ST)对小鼠穹隆下器(SFO)室管膜细胞超微结构的影响。方法:BALB／c小鼠,单次ST(3000 μg/kg) 灌胃,分别于灌胃后1、2、4、8、16 h处死动物,用扫描电镜观察SFO室管膜的结构变化。结果:ST灌胃后1 h部分SFO室管膜表面微绒毛结构消失、细胞破损,ST灌胃后2 h室管膜出现凹凸不平、损伤加重,ST灌胃后8 h室管膜凹凸不平和破损最为明显, ST灌胃后16 h逐渐恢复。结论:提示ST对小鼠SFO室管膜细胞有明显的损伤作用。Objective： To evaluate the effects of single oral sterigmatocystin （ST） on the uhrastructure of the ependemal cells in subfornical organ of BALB/c mice in vivo. Methods.. BALB/c mice were treated intragastrically with lavage of ST at dosage of 3000 μg/kg once. The experimental mice were killed 1, 2, 4, 8 and 16 hours after the oral administration. Uhrastructural changes of ependemal cells of subfornical organ were observed with scanning electron microscopic （SEM） method. Results： After oral administration of ST, the ependymal cells damages were found and the microvilli disappeared in 1 hour; ependymal cells became uneven and the damage became obvious in 2 hours; ependymal cells damage was the most obvious in 8 hours. Conclusion： Ultrastructural changes of the ependemal cells of subfornical organ can be found after single oral administration of ST in mice, suggestting that ST can cause damage to subfornical organ.

关 键 词：穹隆下器 室管膜细胞 杂色曲霉素 小鼠 超微结构 

分 类 号：R361[医药卫生—病理学]