神经胶质瘤缓激肽B2受体和nNOS表达水平与胶质瘤病理级别相关关系的研究  

The Relationship of Expressions of Bradykinin B2 Receptor and nNOS with Pathological Grades of Glioma

作　　者：薛一雪[1] 刘丽波[1] 刘新[1] 

机构地区：[1]中国医科大学基础医学院神经生物学教研室,辽宁沈阳110001

出　　处：《解剖科学进展》2005年第4期315-317,共3页Progress of Anatomical Sciences

基　　金：国家自然科学基金资助项目(No.305706530400145)

摘　　要：目的分析神经胶质瘤缓激肽B2受体和神经元型一氧化氮合酶(nNOS)表达水平与胶质瘤病理级别的相关关系。方法HE染色进行脑肿瘤的病理诊断及分级,免疫组化法测定不同病理级别神经胶质瘤缓激肽B2受体和nNOS的表达水平。结果神经胶质瘤B2受体和nNOS表达水平均与胶质瘤病理级别呈显著正相关,各病理级别神经胶质瘤B2受体和nNOS的表达水平均为:Ⅰ级(Ⅱ级(Ⅲ级。结论神经胶质瘤B2受体和nNOS表达水平均随着其病理级别的增加而升高,提示二者可作胶质瘤病理分级的标示物。Objective To analyze the relationship of expressions of bradykinin B2 receptor and nevre nitric oxide synthase（nNOS） pathological grades of glioma. Methods The clinicopathologic findings were diagnosed by reviewing all HE stained tissue sections, immunohistochemistry was used to dctermine the bradykinin B2 receptor and nNOS expressing levels of glioma . Results There was a significant positive correlation between the expressing levels of bradykinin B2 receptor and nNOS and the pathological grades（ Ⅰ -Ⅲ ） of glioma, the order of the expression levels of bradykinin B2 receptor and nNOS in glioma was grade Ⅰ 〈 grade Ⅱ 〈 grade Ⅲ, Conclusion The higher the pathological grades of glioma, the more expression levels of bradykinin B2 receptor and nNOS, indicates that both could be the marker for the grade of glioma.

关 键 词：缓激肽 B2受体 NNOS 神经胶质瘤 病理级别 

分 类 号：R730.264[医药卫生—肿瘤]