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基于NMDAR1-PSD-nNOS通路探讨栝楼桂枝颗粒对神经元兴奋性毒性损伤后突触可塑性的影响: 《福建中医药》2025年第1期17-21,29,共6页冯怡李雪珍李亚男陈雯婷罗书萍张玉琴; 国家自然科学基金项目(81803768);福建省自然科学基金面上项目(2024J01127);福建中医药大学基础类学科科研提升计划项目(XJC2022009)。; 目的基于NMDAR1-PSD-nNOS通路探讨栝楼桂枝颗粒(GLGZG)对神经元兴奋性毒性损伤后突触可塑性的影响,为GLGZG治疗缺血性脑卒中提供实验依据。方法取新生大鼠的原代海马神经元,分为对照组、模型组、低剂量组、中剂量组,建立N-甲基-D-天冬氨...; 关键词：神经元损伤脑卒中神经可塑性栝楼桂枝颗粒

Neuroprotective effects of Shaoyao Gancao decoction against excitatory damage in PC12 cells based on the Src-NR2-nNOS pathway: 《Journal of Traditional Chinese Medical Sciences》2024年第3期293-302,共10页Xiaoxu Fan Hongyan Ma Tiantian Zhou Min Fu Zhiyuan Qiao Yingtong Feng Zhen Wang Yiwei Shen Jingxia Wang; supported by the National Natural Science Foundation of China(82074036).; Objective:To explore the neuroprotective effects of the Shaoyao Gancao decoction(SGD)against excitatory damage in PC12 cells and the role of the Src-NR2-nNOS pathway mediation by SGD in regulatingγ-aminobutyric acid(...; 关键词：Shaoyao Gancao decoction PC12 N-Methyl-D-aspartic acid(NMDA) γ-aminobutyric acid(GABA) SRC NNOS

活血起萎颗粒对精索静脉曲张合并勃起功能障碍大鼠eNOS、nNOS和Cx43表达的影响被引量：1: 《中国男科学杂志》2024年第2期98-105,共8页陆杰李群生周磊李东润申振南李凝华陈冬唐文平朱璠宇杨文涛; 国家自然科学基金项目(82160905,82260933),广西中医药大学研究生教育创新计划项目(YCBXJ2023019)。; 目的探讨活血起萎颗粒对精索静脉曲张(VC)合并勃起功能障碍(ED)大鼠eNOS、nNOS和Cx43的影响,明确活血起萎颗粒治疗VC合并ED的作用机制。方法将120只SD大鼠分别分为正常组、假手术组、模型组、活血起萎颗粒低、中、高剂量组。通过Turner...; 关键词：精索静脉曲张勃起功能障碍活血起萎颗粒一氧化氮合酶连接蛋白43 大鼠

甲基莲心碱对避水应激大鼠结肠运动的影响及其机制: 《胃肠病学和肝病学杂志》2024年第4期361-364,共4页夏源罗和生; 目的研究甲基莲心碱对避水应激大鼠结肠运动的影响和相关机制。方法建立避水应激大鼠模型,记录造模期间每组大鼠每日平均粪粒数,通过HE染色观察大鼠结肠病理改变。通过RM6240多通道生理信号系统记录造模大鼠体外结肠运动,以及不同浓度...; 关键词：甲基莲心碱避水应激 NNOS 结肠高动力

nNOS-NOS1AP复合体在瑞芬太尼诱发大鼠痛觉过敏中的作用: 《中华麻醉学杂志》2024年第1期66-70,共5页舒瑞辰李媛张璇张增利宋振国尹毅青; 国家自然科学基金(82101351,82001479,81801889);天津市科技计划项目(22JCQNJC01050);天津市医学重点学科(专科)建设项目(TJYXZDXK-009A)。; 目的评价神经元型一氧化氮合酶(nNOS)-一氧化氮合酶1衔接蛋白(NOS1AP)复合体在瑞芬太尼诱发大鼠痛觉过敏中的作用。方法清洁级健康成年雄性SD大鼠40只,体质量240~260 g,2~3月龄,采用随机数字表法分为4组(n=10):对照组(C组)静脉输注生理...; 关键词：瑞芬太尼痛觉过敏一氧化氮合酶Ⅰ型一氧化氮合酶1衔接蛋白

nNOS and Neurological, Neuropsychiatric Disorders: A 20-Year Story被引量：3: 《Neuroscience Bulletin》2023年第9期1439-1453,共15页Li-Juan Zhu Fei Li Dong-Ya Zhu; This review was supported by grants from the National Natural Science Foundation of China(82090042).; In the central nervous system,nitric oxide(NO),a free gas with multitudinous bioactivities,is mainly produced from the oxidation of L-arginine by neuronal nitric oxide synthase(nNOS).In the past 20 years,the studies i...; 关键词：NNOS nNOS-PSD95 nNOS-CAPON nNOS-SERT Neurological and neuropsychiatric disorder

Decoupling SERT-nNOS Interaction to Generate Fast-Onset Antidepressants: 《Neuroscience Bulletin》2023年第8期1327-1329,共3页Qing Ye Si‑Si Lin Henning Ulrich Yong Tang; supported by grants from the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine(ZYYCXTDD-202003);the Science and Technology Program of Sichuan Province,China(2022YFH0006,23RCYJ0059);the São Paulo Research Foundation(FAPESP 2018/07366-4);National Council for Scientific and Technological Development(CNPq,Brasília)(406396/2021-3).; Major depressive disorder(MDD)is one of the most common psychiatric disorders,and~4.7%of the world's population has an onset of depression in any one-year period.It causes constant distress,impairs social function and...; 关键词：DISTRESS HYPOTHESIS clinical

冬季和夏季达乌尔黄鼠下丘脑c-Fos、nNOS和NPY表达及血清激素水平比较: 《野生动物学报》2023年第2期257-265,共9页郑杨慧王恒马小梅王建礼; 国家自然科学基金项目(32160245);宁夏自然科学基金项目(2020AAC03244);北方民族大学高层次人才培养项目(2019BGBZ01)。; 动物通过中枢和外周信号的相互作用调节食欲,达乌尔黄鼠(Spermophilus dauricus)是一种典型的贮脂类冬眠动物。为探究动物冬眠期调节食欲的神经内分泌反应与夏季活动期相比有何不同,通过免疫组织化学方法比较冬季和夏季达乌尔黄鼠下丘脑...; 关键词：达乌尔黄鼠适应下丘脑食欲季节

Insights into human eNOS,nNOS and iNOS structures and medicinal indications from statistical analyses of their interactions with bound compounds: 《Biophysics Reports》2023年第3期159-175,共17页Jianshu Dong DiéLi Lei Kang Chenbing Luo Jiangyun Wang; supported by the National Natural Science Foundation of China(31900913);the support from Shanghai Synchrotron Radiation Facility and National Facility for Protein Science Shanghai(NFPSS);the support from the Postgraduate Education Reform Research Project of Zhengzhou university in 2021(YJSJY202159);the Education Reform Research Project(for international students)of Zhengzhou University in 2022(2022ZZUJGXMLXS-031);the Training Program of Innovation and Entrepreneurship for College Students(Undergraduate Research Training Program,202310459149)。; 83 Structures of human nNOS,55 structures of human eNOS,13 structures of iNOS,and about 126 reported NOS-bound compounds are summarized and analyzed.Structural and statistical analysis show that,at least one copy of e...; 关键词：Nitric oxide synthase Endothelial NOS Neuronal NOS Drug design Molecular pharmacology Inducible NOS

Identification and Pathogen Stimulation Patterns of Neuronal Nitric Oxide Synthase(nNOS)in Black Rockfish(Sebastes schlegelii): 《Journal of Ocean University of China》2023年第3期842-850,共9页YAN Xu WANG Ningning CAO Min LI Chao YANG Ning XUE Ting FU Qiang SONG Lin; supported by the Natural Science Foundation of Shandong Province(No.ZR2020QC214);the Young Experts of Taishan Scholars(No.tsqn201909130);the Science and Technology Support Plan for Youth Innovation of Colleges and Universities in Shandong Province(No.2019KJF003);the‘First Class Fishery Discipline’Programme in Shandong Province;a special talent programme‘One Thing One Decision(YishiYiyi)’Programme in Shandong Province,China;the Breeding Plan of Shandong Provincial Qingchuang Research Team(2019)。; Neuronal nitric oxide synthase(nNOS)was the producer of nitric oxide(NO)which played important gas messenger molecules in biological process.It also can take effect as immune regulation molecule in organism.Black rock...; 关键词：neuronal nitric oxide synthase black rockfish immune function Edwardsiella tarda Vibrio anguillarum

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