Decoupling SERT-nNOS Interaction to Generate Fast-Onset Antidepressants  

作　　者：Qing Ye Si‑Si Lin Henning Ulrich Yong Tang 

机构地区：[1]International Joint Research Centre on Purinergic Signalling/School of Acupuncture and Tuina,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China [2]Department of Biochemistry,Institute of Chemistry,University of São Paulo,São Paulo 05508,Brazil [3]Acupuncture and Chronobiology Key Laboratory of Sichuan Province/School of Health and Rehabilitation,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China

出　　处：《Neuroscience Bulletin》2023年第8期1327-1329,共3页神经科学通报（英文版）

基　　金：supported by grants from the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine(ZYYCXTDD-202003);the Science and Technology Program of Sichuan Province,China(2022YFH0006,23RCYJ0059);the São Paulo Research Foundation(FAPESP 2018/07366-4);National Council for Scientific and Technological Development(CNPq,Brasília)(406396/2021-3).

摘　　要：Major depressive disorder(MDD)is one of the most common psychiatric disorders,and~4.7%of the world's population has an onset of depression in any one-year period.It causes constant distress,impairs social function and physiological health,and even leads to suicide[1].Numerous studies support the classic monoamine hypothesis of depressive episodes.The majority of clinical antidepressants have been developed on the basis of this hypothesis to increase 5-hydroxytryptamine(5-HT).

关 键 词：DISTRESS HYPOTHESIS clinical 

分 类 号：R74[医药卫生—神经病学与精神病学]