牛磺酸对H_2O_2诱发的猪眼白内障的抑制作用及其晶状体中GSH含量的变化  

Studies of the inhibitory role of taurine in the change of glutathione level during H_2O_2-induced cataract in cultured pig lens

作　　者：慕明燕[1] 李晓林[1] 尹少甫[2] 

机构地区：[1]第一人民医院暨兰州医学院附属兰州医院眼科,甘肃省兰州市730050 [2]兰州医学院免疫学教研室

出　　处：《眼科新进展》2005年第6期525-527,共3页Recent Advances in Ophthalmology

摘　　要：目的研究牛磺酸对过氧化氢(H2O2)诱发的白内障的抑制作用及晶状体中抗氧化剂谷胱苷肽含量的变化。方法采用猪晶状体器官培养的方法,观察牛磺酸对H2O2诱发猪晶状体白内障形成的抑制作用,同时检测对照组、H2O2组和H2O2+牛磺酸组猪晶状体中谷胱苷肽的含量。结果随着培养时间的延长,H2O2+牛磺酸组晶状体混浊程度明显较H2O2组轻,且H2O2+牛磺酸组晶状体中谷胱苷肽含量明显高于H2O2组,差异有显著统计学意义(P<0.01)。结论牛磺酸做为抗氧化剂,能抑制H2O2诱发的猪晶状体中抗氧化剂谷胱苷肽的减少,从而延迟白内障的发生和发展。Objective To study the inhibitory role of taurine in the change of glutathione（GSH） level during H2O2-induced cataract in cultured pig lens. Methods The inhibitory role of taurine in H2O2-induced cataract in cultured pig lens was observed, and the concentrations of GSH in control group lens, H2O2 group lens and H2O2 treated by taurine group lens were measured at different cultured times. Results The occurance of lens opaque was remarkly delayed after taurine treatment,and the concentration of GSH in H2O2 treated by taurine group lens was significantly increased than that in H2O2 group（P〈0.01）. Conclusion Taurine can prevent GSII on H2O2-induced cataract in cultured pig lens to delay the occurrence and development of cataract.

关 键 词：牛磺酸 白内障 谷胱苷肽 猪 

分 类 号：R776.1[医药卫生—眼科]