Study on 4977-bp deletion mutation of mitochondrial DNA in lung cancer  

作　　者：戴纪刚 肖颖彬 闵家新 张国强 姚珂 周人杰 

机构地区：[1]Department of Thoracic Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China

出　　处：《Journal of Medical Colleges of PLA(China)》2005年第6期345-350,共6页中国人民解放军军医大学学报（英文版）

基　　金：SupportedbyDevelopmentalProgrammingItemofNa-tionalKeystoneBasicResearch(G2000016106)andNatureScienceFoundationofChongqing(2005).

摘　　要：Objective: To study the 4977-bp deletion of mitochondiral DNA in lung cancer, adjacent normal tissue and health lung and its significance in the development of cancer. Methods:Thirty-seven matched lung cancer/adjacent histologically normal and 20 “true” normal lung tissue samples from patients without lung cancer were analyzed by long PCR technique. Results: Mitochondrial DNA 4977-bp deletion was detected in 54.1% (20/37) of lung cancers, 59.5% (22/37) of adjacent normal and 30.0% (6/30) of “true” normal lung tissues. The correlation of 4977-bp deletion with age and smoking factors was present in our data. Conclusion: Mitochondrial DNA 4977-bp deletion is not specific to lung cancer and unlikely to play an important role in carcinogenesis, and may only reflect the environmental and genetic influences during tumor progression.Objective： To study the 4977-bp deletion of mitochondiral DNA in lung cancer, adjacent normal tissue and health lung and its significance in the development of cancer. Methods： Thirty-seven matched lung cancer/adjacent histologically normal and 20 ＂true＂ normal lung tissue samples from patients without lung cancer were analyzed by long PCR technique. Results： Mitochondrial DNA 4977-bp deletion was detected in 54.1% （20/37） of lung cancers, 59.5% （22/37） of adjacent normal and 30.0% （6/30） of ＂true＂ normal lung tissues. The correlation of 4977-bp deletion with age and smoking factors was present in our data. Conclusion.. Mitochondrial DNA 4977 bp deletion is not specific to lung cancer and unlikely to play an important role in carcinogenesis, and may only reflect the environmental and genetic influences during tumor progression.

关 键 词：mitochondrial DNA lung cancer DELETION 

分 类 号：R734.2[医药卫生—肿瘤]