DELETION

作品数：398被引量：945H指数：16
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相关领域：医药卫生生物学更多>>
相关作者：徐春林蒋瑞瑞刘小军李转见王丹丹更多>>
相关机构：河南农业大学复旦大学南京农业大学江苏农业科学院更多>>
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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression
《Neural Regeneration Research》2025年第11期3259-3272,共14页Huidong Li Faqin Li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni Li Haojie An Shiyi Zeng Chunyan Wang Li Yang Cheng Long 
supported by the National Natural Science Foundation of China,Nos.32371065(to CL)and 32170950(to LY);the Natural Science Foundation of the Guangdong Province,No.2023A1515010899(to CL);the Science and Technology Projects in Guangzhou,Nos.2023A4J0578 and 2024A03J0180(to CW)。
Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear memory.Cylindromatosis(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-...
关键词：basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission 
Prevalence of RUNX1 gene alterations in de novo adult acute myeloid leukemia
《World Journal of Experimental Medicine》2025年第1期65-79,共15页Hoda M Abd El-Ghany Mona S El Ashry Mona S Abdellateif Ahmed Rabea Nada Sultan Omnia Y Abd El Dayem 
BACKGROUND Acute myeloid leukemia(AML)is a complicated disease with uncontrolled hematopoietic precursor proliferation induced by various genetic alterations.Runt-related transcription factor-1(RUNX1)is commonly disru...
关键词：Acute myeloid leukemia DELETION Disease-free survival Fluorescence in-situ hybridization KARYOTYPING RUNX1 
Heterozygous deletion of Cul4b in female mice leads to ovulatory dysfunction and female infertility
《Genes & Diseases》2025年第1期122-125,共4页Yufeng Wang Yuting Liu Wei Jiang Yu Song Yongxin Zou Molin Wang Qiao Liu Gongping Sun Yaoqin Gong Baichun Jiang 
supported by the National Natural Science Foundation of China(No.31970559,82171851,32370652).
It is estimated that infertility impacts 8%-12%of reproductive-aged couples worldwide.Female infertility accounts for 37%of causes among infertile couples,and ovulatory dysfunction is regarded as its most common facto...
关键词：INFERTILITY FEMALE DYSFUNCTION 
Wdr63 Deletion Aggravates Ulcerative Colitis Likely by Affecting Th17/Treg Balance and Gut Microbiota
《生物化学与生物物理进展》2025年第1期209-222,共14页ZHU Hao ZHU Meng-Yuan CAO Yang-Yang YANG Qiu-Bo FAN Zhi-Peng 
国家自然科学基金(82130028);国家重点研发计划(2022YFA1104401);中国医学科学院医学创新基金(2019-I2M-5-031);首都医科大学北京口腔医院创新研究项目(CXTD202204)资助。
Objective Ulcerative colitis is a prevalent immunoinflammatory disease.Th17/Treg cell imbalance and gut microbiota dysregulation are key factors in ulcerative colitis pathogenesis.The actin cytoskeleton contributes to...
关键词：Wdr63 TH17/TREG ulcerative colitis inflammation immune MICROBIOLOGY 
Glaucomatous retinal ganglion cells:death and protection
《International Journal of Ophthalmology(English edition)》2025年第1期160-167,共8页Na Cui Jun Jia Yuan He 
Supported by National Natural Science Foundation of China(No.82070964);Shaanxi Provincial Outstanding Youth Science Foundation Project(No.2022JC-60);Shaanxi International Science and Technology Cooperation Program Project(No.2024GHYBXM-20);Shaanxi Provincial Education Department Youth Innovation Team Research Project(No.23JP151).
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration,with the characteristic pathological change being death of retinal ganglion cells(RGCs),which ultimately causes visual field loss a...
关键词：GLAUCOMA retinal ganglion cells NEUROPROTECTION progressive death axonal deletion 
Deletion of Salmonella pathogenicity islands SPI-1, 2 and 3 induces substantial morphological and metabolic alternation and protective immune potential
《Journal of Integrative Agriculture》2025年第1期272-289,共18页Gaosong Liu Xuelian Lü Qiufeng Tian Wanjiang Zhang Fei Yi Yueling Zhang Shenye Yu 
supported by the National KeyR&DProgramof China(2022YFF0710500);the National Natural Science Foundation of China(32172853 and 32373013);the Central Public-interest Scientific Institution Basal Research Fund,China(1610302022001).
The Salmonella pathogenicity islands(SPIs) play crucial roles in the progression of Salmonella infection. In this study, we constructed an improved λ Red homologous recombination system to prepare single and triple d...
关键词：Salmonella pathogenicity islands(SPls) morphology carbon source metabolism PATHOGENICITY IMMUNOGENICITY live attenuated vaccine 
Versatile and efficient mammalian genome editing with Type Ⅰ-C CRISPR System of Desulfovibrio vulgaris被引量：1
《Science China(Life Sciences)》2024年第11期2471-2487,共17页Pan Li Dingcai Dong Fei Gao Yuyang Xie Honglin Huang Siwei Sun Zhao Ma Cheng He Jinsheng Lai Xuguang Du Sen Wu 
funded by the National Key R&D Program of China(2021YFA0805900,2023YFF1000200,2023YFF1000900,and 2023YFC3402004);the China Postdoctoral Science Foundation(2021M703521).
CRISPR-Cas tools for mammalian genome editing typically rely on single Cas9 or Cas12a proteins.While type I CRISPR systems in Class I may offer greater specificity and versatility,they are not well-developed for genom...
关键词：type I CRISPR systems Desulfovibrio vulgaris Dvu type I-C editor define deletion large fragment replacement base editing 
Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium
《Genes & Diseases》2024年第5期335-349,共15页Jinxuan Zheng Rongcheng Yu Yiqi Tang Sihui Su Sainan Wang Chenxi Liao Xuecong Li Jiabin Liao Dongsheng Yu Tingting Ai Wei Zhao Vicky Yau Chufeng Liu Liping Wu Yang Cao 
the National Natural Science Foundation of China(No.81900958,82170987,82073378,81974146,82101053);the Natural Science Foundation of Guangdong Province,China(No.2020A1515-010059,2021A1515012535);Sun Yat-Sen University Clinical Research 5010 Program(No.2023009);Science and Technology Planning Project of Guangzhou,China(No.2023-A04J2148);Open Funding of Guangdong Provincial Key Laboratory of Stomatology(China)(No.KF2021120104).
Developmental defects of enamel are common due to genetic and environmental factors before and after birth.Cdc42,a Rho family small GTPase,regulates prenatal tooth development in mice.However,its role in postnatal too...
关键词：CDC42 Enamel defects Mitochondrial dysfunction Rho GTPase Tooth repair 
Deletion of Luzp Does Not Cause Hearing Loss in Mice
《Neuroscience Bulletin》2024年第10期1519-1528,共10页Cheng Cheng Guangjie Zhu Kaijian Wang Chuan Bu Siyu Li Yue Qiu Jie Lu Xinya Ji Wenli Hao Junguo Wang Chengwen Zhu Ye Yang Yajun Gu Xiaoyun Qian Chenjie Yu Xia Gao 
supported by grants from the National Natural Science Foundation of China (81970884,81900941,81970885,82371157,82171145,82271173,and 81771019);the Natural Science Foundation of Jiangsu Province (BK20190121 and BK20200133);the China Postdoctoral Science Foundation (2020M681555);a Distinguished Young Scholarship supported by the Medical Science and Technology Development Foundation,Nanjing Department of Health (JQX20003).
Deafness is the prevailing sensory impairment among humans,impacting every aspect of one's existence.Half of congenital deafness cases are attributed to genetic factors.Studies have shown that Luzp2 is expressed in ha...
关键词：Hearing loss Luzp2 Hair cell Stereocilia Ribbon synapse 
Deletion of V483 in the spike confers evolutionary advantage on SARS-CoV-2 for human adaptation and host-range expansion after a prolonged pandemic
《Cell Research》2024年第10期739-742,共4页Can Yue Shuo Liu Bo Meng Kaiyue Fan Sijie Yang Pan Liu Qianhui Zhu Xin Mao Yuanling Yu Fei Shao Peng Wang Youchun Wang Ravindra Kumar Gupta Yunlong Cao Xiangxi Wang 
supported by the National Key R&D Program(2023YFC2306000 and 2018YFA0900801);the Ministry of Science and Technology of China(CPL-1233 and SRPG22-003),CAS(YSBR-010);the National Science Foundation Grants(12034006,32325004 and T2394482);supported by the National Science Fund for Distinguished Young Scholar(32325004);the NSFS Innovative Research Group(81921005).
Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has undergone continuous evolution since its initial outbreak in 2019.The emergence of Omicron as the dominant variant occurred abruptiy after 202...
关键词：sustained residue EXPANSION 
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