硒性白内障的实验模型研究  

Study on Experimental Cataract Model Induced by Selenite

作　　者：濮祖茂[1] 季晖[1] 龚国清[1] 周曙[1] 孙晓明[1] 李耐三[1] 徐黻本 

机构地区：[1]中国药科大学电镜室

出　　处：《中国药科大学学报》1996年第2期102-105,共4页Journal of China Pharmaceutical University

摘　　要：０．１％亚硒酸钠０．０２６ｍｌ／ｋｇ给１２日龄大鼠一次性ｓｃ造成硒性白内障模型，用裂隙灯镜检分级记分，扫描电镜微观形态分析，测定晶体ＭＤＡ含量及不溶性和高分子量蛋白病理生化测定等多项指征进行综合评价和分析，证实该模型成功率在９０％以上，为考察药物对不同类型白内障的防治作用奠定基础。The selenite cataract model was made by means of subcutanaous injection at a single dose of 0.2 6 ml/kg to twelve-day old rats.The model was evaluated by slit lamp cataract grading,scanning electron microscopy and by biochemical measurement of the contents of MDA,insoluble protein and high molecular weight protein in lenses.The results showed that the successful rate of the model was higher than90%,and suggested that the model could be used as an assessment of the prevention and treatment effects of drugs on various cataracts.

关 键 词：白内障 亚硒酸钠 扫描电镜 裂隙灯镜检 

分 类 号：R776.102[医药卫生—眼科]