壳聚糖的毒性研究  

STUDY ON TOXICITY OF CHITOSAN.

作　　者：程东[1] 韩晓英[2] 冯宁[1] 张天亮[1] 李慧[1] 

机构地区：[1]山东省疾病预防控制中心,济南250014 [2]山东大学毒理学研究所

出　　处：《现代预防医学》2006年第2期162-164,共3页Modern Preventive Medicine

摘　　要：目的:研究壳聚糖的毒性。方法:小鼠急性毒性试验、Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验、大鼠30 d喂养试验。结果:壳聚糖属实际无毒物质;Ames试验、微核试验和精子畸形试验结果均为阴性;大鼠30 d喂养试验结果显示该样品30 d喂养对大鼠各项观察指标未见毒性作用。结论:在本次实验条件下,壳聚糖为无毒物质,未显示有遗传毒性和亚急性毒性作用。Objective： To study the loxicity of chitosan. Methods： Acute toxicity test of mice, Ames test, micronucleus test of bone marrow PCE cell in mice, sperm shape abnormality test of mice, thirty days feeding study were done. Results, Chitosan was a substance with no toxicity. The results of genetic toxicity test were all negative, including Ames test,micronucleus test and sperm shape abnormality test. The results of thirty days feeding study was also negative. Conclusion. Chitosan is a substance with no toxicity and have no genetic toxicity and subacute toxicity under the condition of this test.

关 键 词：壳聚糖 急性毒性试验 遗传毒性试验 大鼠30 d喂养试验 

分 类 号：R15[医药卫生—营养与食品卫生学]