Further Investigation on the Rearrangement Mechanism of Reactions of 1,5-Benzothiazepines with Ethoxycarbonylcarbene  

作　　者：WU Chun-zan HUANG Jia-xing ZHANG Qi-han XU Jia-xi 

机构地区：[1]Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China

出　　处：《Chemical Research in Chinese Universities》2006年第1期36-39,共4页高等学校化学研究（英文版）

基　　金：SupportedpartlybytheNationalNaturalScienceFoundationofChina(Nos.20272002and20472005),MinistryofEducationofP.R.China(SRFforROCSandEYTP)andPekingUniversity(PresidentGrant).

摘　　要：The reactions of 2,3-dihydro-1,5-benzothiazepines with ethoxyearbonylcarbene undergo complex rearrangements to produce rlng-opening and ring contraction products. Previously it was presumed that the different products were formed via different mechanisms depending on the kind of substituents at the 2-position of 1,5-benzothiazepines. However, on the basis of the further detailed investigation, it was found that all 1,5-benzothiazepines can undergo the same rearrangement to yield both ring-opening and ring contraction products.The reactions of 2,3-dihydro-1,5-benzothiazepines with ethoxyearbonylcarbene undergo complex rearrangements to produce rlng-opening and ring contraction products. Previously it was presumed that the different products were formed via different mechanisms depending on the kind of substituents at the 2-position of 1,5-benzothiazepines. However, on the basis of the further detailed investigation, it was found that all 1,5-benzothiazepines can undergo the same rearrangement to yield both ring-opening and ring contraction products.

关 键 词：1 5-BENZOTHIAZEPINE Ethoxycarbonylcarbene REARRANGEMENT RING-CONTRACTION RING-OPENING 

分 类 号：O626.4[理学—有机化学] O643.12[理学—化学]