吲哚基丁烯酮缩氨基硫脲配合物的合成及生物活性  

Synthesis and biological activities of transition metal complexes with the schiff base ligand indolyi substituted 3-buten-2-one thiosemicarbazone

作　　者：孙纲春[1] 曲建强[2] 王流芳[2] 陈耐生[1] 陈晓光[3] 李燕[3] 谢晶曦[3] 

机构地区：[1]福州大学功能材料研究所,福建福州350002 [2]兰州大学应用有机化学国家重点实验室,甘肃兰州730000 [3]中国医学科学院中国协和医科大学药物研究所,北京100050

出　　处：《化学研究与应用》2006年第1期85-88,共4页Chemical Research and Application

基　　金：国家自然科学基金资助项目(No.50272027)

摘　　要：A new Schiff base ligand 4-[1-（toluene-4-sulfony1）-indol-3-y1]-3-but-en-2-one thiosemicarbazone（HL）and its four transition metal complexes(（ML2,M=Cu（Ⅱ）,Ni（Ⅱ）,Zn（Ⅱ） and Co（Ⅱ）） have been prepared and characterized by means of elemental analyses,molar conductivity and IR,In vitro antitumor activity of the ligand and the complexes was studied by using MTT method,Their antibacterial activity was studied using the filter scraps diffusion method.A new Sehiff base ligand 4 - [ 1 - （ toluene - 4 - sulfony1 ） L indol - 3 - y1 ] - 3 - but - en - 2 - one thioscmicarbazone （HL） and its four transition metal complexes（ （ ML2 ,M = Cu（ Ⅱ ） ,Ni（Ⅱ） ,Zn（ Ⅱ ） and Co（ Ⅱ ） ） have been prepared and characterized by means of elemental analyses,molar conductivity and IR,In vitro antitumor activity of the ligand and the complexes was studied by using MTT method,Their antibacterial activity was studied using the filter scraps diffusion method.

关 键 词：缩氨基硫脲 过渡金属配合物 合成 生物活性 

分 类 号：O614.121[理学—无机化学] O614.81[理学—化学]