磺氨基醇手性配体的合成及钛配合物催化二乙基锌对醛的不对称加成反应  

Synthesis of Sulfonylated Amino Alcohols and Asymmetric Addition of Diethylzinc to Aldehydes Catalyzed by Titanium Complexes

作　　者：惠新平[1] 乔仁忠[1] 许鹏飞[1] 

机构地区：[1]兰州大学功能有机分子化学国家重点实验室,兰州730000

出　　处：《有机化学》2006年第2期211-214,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20021001);甘肃省自然科学基金(No.3ZS051-A25-005)资助项目.

摘　　要：合成了手性磺氨基醇配体3～5,将这些配体和Ti(O-i-Pr)4应用于二乙基锌对醛的不对称加成反应,获得了好的对映选择性,ee值最高为91%.Sulfonylated amino alcohols 3-5 were prepared and the asymmetric addition of diethylzinc to aldehydes catalyzed by titanium complexes of those ligands was carried out. Good enantioselectivities were obtained with ee values up to 91%.

关 键 词：磺氨基醇 (+)-10-樟脑磺酰氯 二乙基锌 Ti(O-i-Pr)4 不对称加成反应 手性配体 氨基醇 钛配合物 合成 催化 

分 类 号：O641.4[理学—物理化学] O621.25[理学—化学]