莲房原花青素对^(60)Co-γ射线致免疫器官损伤的防护作用  

Study on Protection of Proanthocyaidins from Lotus Seedpod (LSPC) on Subchronic Damage Caused by ^(60)Co-γ Radiaton

作　　者：段玉清[1,2] 张海晖[1] 唐瑛[3] 吴佳[4] 谢笔钧[4] 

机构地区：[1]江苏大学生物与环境学院 [2]华中农业大学食品科技学院,湖北武汉430070 [3]广州军区武汉总医院 [4]华中农业大学食品科技学院

出　　处：《食品科学》2006年第1期220-222,共3页Food Science

基　　金：国家自然科学基金(30270938);博士点基金(20040504013);江苏省教育厅自然基金(05KJB550011)

摘　　要：目的:研究莲房原花青素(LSPC)对60Co-γ射线致小鼠脏器损伤的影响。方法:给小鼠连续灌胃不同剂量的LSPC15d后,接受剂量4.0Gy60Co-γ射线照射后,于第3d处死小鼠,测定脏器增长指数并进行形态学观察。结果:小鼠经4.0Gy60Co-γ一次全身辐照后,100、200mg/kgbwLSPC组能使小鼠脾脏和胸腺增长指数明显提高,且与辐射对照组间有显著性差异(分别为p<0.01和p<0.05)。LSPC可不同程度的保护或恢复60Co-γ射线致小鼠的脾脏、胸腺的损伤。结论:LSPC对4.0Gy60Co-γ射线亚慢性辐射致免疫器官损伤有一定的保护作用。Objective： Investigation on protection effects of proanthocyanidins from Lotus Seedpod （LSPC） on mice viscera damage caused by ^60Co-γ radiation. Methods Mice were given different dosages of LSPC continuously for 15 days by gavage, then exposed to 4.0 Gy ^60Co-γ radiation, the mice were killed after 3 days exposure and assayed for viscera increase index with additional morphology observation, Results After mice were exposed to 4.0 Gy ^60Co-γ, the increase index of mice spleen and thymus were up to 100, 200mg/kg bw respectively, and showed significiant difference to the control group （p 〈 0.01 and p 〈 0.05 respectively）, LSPC can protect or restore mice spleen and thymus damages caused by ^60Co-γ. Conclusions ： LSPC had a certain of protective effect on subchronic damages to viscera by 4.0 Gy ^60Co-γ.

关 键 词：莲房 原花青素 抗辐射 脏器 

分 类 号：Q691.9[生物学—生物物理学]