p27^(kip1)和p57^(kip2)在宫颈癌组织中的表达及其预后意义  

Expressions of p27^(kip1) and p57^(kip2) in human cervix carcinoma and their prognostic significance.

作　　者：郭伟平[1] 王泽华[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院妇产科,武汉430022

出　　处：《现代妇产科进展》2006年第1期32-35,共4页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨细胞周期调控抑制因子p27^(kip1)和p57^(kip2)在宫颈癌发生发展中的作用及预后意义。方法:采用免疫组化二步法检测p27^(kip1)和p57^(kip2)在48例宫颈癌(宫颈癌组)、13例宫颈上皮内瘤变(CIN组)和15例正常宫颈组织(正常组)中的表达。结果:p27^(kip1)和p57^(kip2)在宫颈癌组中的阳性表达率分别为25·00%和20·83%,显著低于正常组和CIN组(P<0·01,P<0·01),而后两组比较差异无统计学意义(P>0·05)。p27^(kip1)表达与宫颈癌病理分化程度显著相关(P<0·01);p57^(kip2)表达与宫颈癌病理分化程度及肿瘤大小有关(P<0·05,P<0·05);两者均与临床分期、组织学类型及淋巴结转移无关(均P>0·05)。p27^(kip1)与p57^(kip2)表达呈极显著正相关(r=0·621,P<0·01)。Kaplan-Meier单因素分析宫颈癌患者生存时间与p27^(kip1)及p57^(kip2)阳性表达有关(P<0·05,P<0·01)。结论:p27^(kip1)和p57kip2的低表达或缺失可能在宫颈癌发生发展中起重要作用,可能与预后不良有关。Objective： To investigate the roles of the inhibitory factors of cell cycle regulation p27^kip1 and p57^kip2 in the development and advancement of the human cervix carcinoma and their clinicopathological and prognostic significance. Methods ：The expressions of p27^kip1 and p57^kip2 in tumor tissues of 48 patients with cervix carcinoma and 13cases with cervical intraepithelial neoplasia（CIN） and 15 cases with normal cervical epithelium were detected by PolyHRP immunohistochemical technique. Results： p27^kip1 and p57^kip2 positive-expression rate in tumor tissues of cervix carcinoma was 25.00% and 20. 83% respectively, which were lower than those in CIN and normal cervical epithelial tissues （P 〈 0. 01, P 〈 0.01 ）, and there was no significant difference in p27^kip1 and p57^kip2 staining between normal cervical epithelium and CIN groups（P 〉 0. 05 ）. p27^kip1 positive-expression correlated significantly with tumor cell differenti- ation（P 〈0. 01 ）. p57^kip2 positive-expression correlated significantly with tumor cell differentiation and lesion size （ P 〈 0. 05, P 〈 0. 05 ）. p27^kip1 positive-expression correlated significantly with p57^kip2 positive-expression （ r = 0. 621, P 〈 0. 01 ）. Kaplan-Meier estimation indicated that survival might be related to p27k^kip1 and p57^kip2 （ P 〈 0. 05, P 〈 0. 01 ） . Conclusion ： The decreased expression or loss of p27^kip1 and p57^kip2 may play an important role in the development and progression of the cervical carcinoma, which is associated with poor prognosis.

关 键 词：宫颈肿瘤 宫颈上皮内瘤变 P27^KIP1 P57^KIP2 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]