吗啡疫苗接种小鼠对吗啡药理作用的影响  

Effects of anti-morphine vaccines on pharmacological actions of morphine in mice

作　　者：李琳[1] 徐江平[1] 富宁[2] 

机构地区：[1]南方医科大学药学院药理系,广东广州510515 [2]南方医科大学基础部免疫学教研室,广东广州510515

出　　处：《中国药理学通报》2006年第1期81-84,共4页Chinese Pharmacological Bulletin

基　　金：广东省广州市科技攻关资助项目(No2002Z3-E4102)

摘　　要：目的观察两种吗啡疫苗接种小鼠对吗啡药理作用的影响。方法吗啡及吗啡半酯在碳二亚胺催化下分别与B lue Carrier(BC)载体蛋白交联制备吗啡疫苗(M-BC、M-6-S-BC),用其免疫小鼠,观察免疫小鼠对吗啡戒断症状及吗啡镇痛作用的影响。结果与吗啡模型组比较,两种疫苗免疫接种可使吗啡戒断症状减轻,使跳跃潜伏期延长(P<0.05),跳跃次数显著减少(P<0.01);M-BC及M-6-S-BC组的平均扭体次数与吗啡治疗组比较差异有显著性(P<0.05)。结论两组吗啡疫苗均可诱导机体产生特异性抗吗啡抗体,该抗体能够部分中和体内的吗啡,阻止吗啡吸收入脑,缓解吗啡产生的身体依赖性,对抗吗啡的戒断作用及镇痛作用。Aim To investigate the effects of anti-morphine vaccines on pharmacological actions of morphine in mice. Methods Morphine-6-succinyl and morphine were conjugated respectively with Blue Carrier （BC） in the presence of carbodi-imide. After being immunized with both vaccines （ M-BC, M-6-S-BC） , the withdrawal syndrome and the abirritation were observed in mice. Results The withdrawal syndrome of the immune mice with M-6-S-BC and M-BC vaccines were reduced markedly compared with the model group, the skipping times were decreased and the latency was longer（ P 〈 0.05, P 〈 0.01 ） ;The abirritation was decreased markedly compared with that in the model group （ P 〈 0.05 ）. Conclusions Both morphine vaccines can elicit a high-titer antibody response and block the morphine to enter the brain and weaken the effects of morphine on CNS.

关 键 词：吗啡 疫苗 免疫疗法 戒断症状 

分 类 号：R-332[医药卫生] R392.11