河南贲门癌高发区贲门癌组织ATP7B的表达  

Expression of ATP7B in human gastric cardia adenocarcinoma tissue from high incidence area in Henan

作　　者：范宗民[1] 吴达龙[1] 高珊珊[1] 何欣[1] 赵颖颖[2] 易会兴[1] 冯常炜[2] 李吉林 焦新英 张延瑞[4] 王立东[1] 

机构地区：[1]郑州大学医学实验中心癌症研究室河南省食管癌重点开放实验室郑州大学第一附属医院内科,郑州450052 [2]郑州大学第二附属医院消化内科,郑州450014 [3]林州市姚村食管癌医院病理科,林州456592 [4]河南省人民医院消化内科,郑州450003

出　　处：《郑州大学学报（医学版）》2006年第1期54-56,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家杰出青年科学基金资助项目30025016;河南省高校创新人才工程基金资助项目1999125;河南省医学科技攻关基金资助项目20058;河南省食管癌重点开放实验室基金资助项目20050227;郑州大学211工程基金资助项目

摘　　要：目的:了解贲门癌组织中ATP7B的表达情况。方法:采用免疫组化ABC法检测49例河南贲门癌高发区贲门癌及其相应癌旁正常组织中ATP7B的表达。结果:ATP7B在贲门癌组织中阳性表达率为51%(25/49),高于癌旁正常组织中的29%(14/49),差异有统计学意义(χ2=5.15,P<0.05)。贲门癌组织ATP7B表达与肿瘤体积、淋巴结转移和远处转移无关,而与肿瘤分化程度有关。结论:ATP7B在贲门癌对铂类抗肿瘤药的先天耐药形成过程中发挥了重要作用,ATP7B可作为贲门癌的预后判断指标。Aim： To explore the expression of ATPTB in human gastric cardia adenocarcinoma（GCA） and its significance. Methods： The expression of ATPTB in 49 cases of human GCA and the corresponding adjacent non-neoplastic epithelium tissue was detected using immunohistochemical ABC method. Results： The rate of ATP7B expression in GCA was 51% （25/49） , and higher than 29% （14/49） of the corresponding adjacent non-neoplastic epithelium （X2 = 5. 15, P 〈 0.05）. No significant association was found between ATP7B expression and tumor size, metastasis and nodal stage. ATPTB expression in poorly differentiated carcinoma was significantly higher than that in well and moderately differentiated carcinoma（P 〈0.05）. Conclusion： ATP7B protein might play an important role in de novo resisitance of GCA cells to cisplatin,and ATPTB expression might serve as a prognostic factor.

关 键 词：贲门癌 ATP7B 耐药 顺铂 

分 类 号：R735.1[医药卫生—肿瘤]