米托蒽醌-胰岛素偶联物及其冻干粉针性能研究  

Investigation on the Properties of Mitoxantrone-Insulin Conjugates Lyophilized Powder

作　　者：刘文胜[1] 张志荣[2] 黄园[2] 

机构地区：[1]首都医科大学化学生物学与药学院,北京100054 [2]四川大学华西药学院药剂教研室,成都610041

出　　处：《生物医学工程学杂志》2006年第1期90-92,共3页Journal of Biomedical Engineering

基　　金：国家杰出青年基金资助项目(39925039)

摘　　要：设计以胰岛素为抗癌药物肿瘤导向载体,合成了米托蒽醌含量为11.68%的米托蒽醌-胰岛素偶联物。体外稳定性试验表明,偶联物在37℃不同pH值缓冲液中及小鼠血浆中稳定。将偶联物制成冻干粉针剂,考察了制剂的药剂学性质,并通过动物实验证实偶联物中的胰岛素仍保持生物活性。In this study we prepared mitoxantrone-insulin conjugate wherein mitoxantrone was an anticancer model drug and insulin acted as its vector leading to tumor cells. The drug loading of the conjugate was determined to be 11.68%. Stability trials of the conjugate were carried out in different pH buffer solutions and mouse plasma under 37℃, which showed the stability of the conjugate in vitro. Lyophilized powder was prepared and its pharmaceutical qualities were assessed. The retained biological activity of the insulin within the conjugate, demonstrated by animal experiments.

关 键 词：胰岛素 载体 米托蒽醌 偶联物 冻干粉针 

分 类 号：R914[医药卫生—药物化学]