Hepatotoxicity of anti-inflammatory and analgesic drugs:ultrastructural aspects  

作　　者：Irena MANOV Helen MOTANIS Idan FRUMIN Theodore C IANCU 

机构地区：[1]Pediatric Research and Electron Microscopy Unit.Ruth and Baruch Rappaport Faculty of Medicine,Technion-Israel Institute of Technology,Haifa 31096.Israel

出　　处：《Acta Pharmacologica Sinica》2006年第3期259-272,共14页中国药理学报（英文版）

基　　金：Project supported in part by the Dan David Foundation and the Milman Fund for Pediatric Research;Dr Manov was supported by the Kamea Fund.

摘　　要：With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ultrastructural findings, which may contribute to the comprehension and possible avoidance of drug-induced liver disease. We also present some original observations on clinical material and cultured cells exposed to acetaminophen alone or in combination with the antioxidant N-acetylcysteine or the P-glycoprotein inhibitor verapamil.With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ultrastructural findings, which may contribute to the comprehension and possible avoidance of drug-induced liver disease. We also present some original observations on clinical material and cultured cells exposed to acetaminophen alone or in combination with the antioxidant N-acetylcysteine or the P-glycoprotein inhibitor verapamil.

关 键 词：non-steroidal anti-inflammatory agents drug toxicity liver ASPIRIN ACETAMINOPHEN cultured cells electron microscopy apoptosis P-GLYCOPROTEIN ACETYLCYSTEINE 

分 类 号：R971[医药卫生—药品]