Synthesis of a New Series of Bone Affinity Compounds  

作　　者：Ying WANG Hong CHEN Zong Ming WAN Mao Sheng CHENG Xue Chao WANG Guo Liang CONG Sheng JING Zi Ping YAN Bo WU 

机构地区：[1]Medical College of Chinese People＇ s Armed Police Force, Tianjin 300162 [2]Shenyang Pharmaceutical University, Shenyang 110016

出　　处：《Chinese Chemical Letters》2006年第3期310-312,共3页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China （No.30371682）.

摘　　要：A new series of bone affinity compounds were synthesized by linking chrysophanol with 5-fluorouracil derivatives. Their bone affinity was established by hydroxyapative （HA） affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay.A new series of bone affinity compounds were synthesized by linking chrysophanol with 5-fluorouracil derivatives. Their bone affinity was established by hydroxyapative （HA） affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay.

关 键 词：CHRYSOPHANOL 5-FLUOROURACIL bone affinity antitumor. 

分 类 号：R979.1[医药卫生—药品] R914[医药卫生—药学]