重组人骨形成蛋白牙槽嵴内诱导成骨的实验研究  

Study of Recombinant Human Bone Morphogenetic Proteins-7(BMP-7) to Induce Bone Formation in Extraction Socket

作　　者：肖水清[1] 张体勇 田华[1] 

机构地区：[1]济南市口腔医院正畸科,山东济南250001 [2]枣庄市第四医院

出　　处：《口腔医学研究》2006年第1期47-49,共3页Journal of Oral Science Research

摘　　要：目的：探讨原核表达重组人骨形成蛋白-7牙槽嵴内诱导成骨的作用效果。方法：拔除大白兔的切牙建立动物模型，以明胶海绵作为载体，将原核表达的重组人骨形成蛋白-7与之复合后植入即刻拔除牙齿的牙槽窝内进行干预治疗，通过扫描电镜观察及钙含量测定，探讨原核表达重组人骨形成蛋白-7牙槽嵴内诱导成骨的作用效果。结果：扫描电镜观察显示：实验组的骨创愈合比对照组大约提前4—6周；钙含量测定显示实验组明显高于对照组。差异有统计学意义。结论：重组人骨形成蛋白-7具有良好的诱导牙槽嵴内成骨的效果。Objective： To explore the machanism of recombinant human bone morphogenetic proteins -7 （BMP- 7 ） to induce bone formation in extraction socket. Methods： We set up the model of rabbit extraction socket into which the composites of BMP - 7 and the gelatin sponge were implanted, then the osteoinduction of BMP - 7 was assessed by histological method, and quantitative measurement of calcium content. Results： The result of histology showed that bone healed in BMP - 7 groups earlier for 4 - 6 weeks than that of control groups. Calcium content in BMP - 7 groups was obviously higher compared with that of control groups. Conclusion： The BMP -7 has a satisfactory osteoinduction ability to promote extration socket healing and prevent alveolar bone absorption.

关 键 词：重组人骨形成蛋白-7 牙槽嵴 扫描电镜 实验 

分 类 号：R783.5[医药卫生—口腔医学]