乳牙菌斑液短链有机酸含量的分析研究  

Analytical study of short-chain organic acids in dental plaque fluid of primary teeth

作　　者：梁惠霞[1] 石四箴[1] 

机构地区：[1]同济大学儿童口腔医学研究所,上海现在南京市口腔医院工作200032

出　　处：《上海医学》2006年第2期98-100,共3页Shanghai Medical Journal

摘　　要：目的研究蔗糖溶液漱口前、后乳牙菌斑液短链有机酸含量与龋病易感性的关系。方法3～5岁完整乳牙列幼儿32例，无龋组12例[龋补牙数（dft）=0且龋蚀指数（CSI）=0]；有龋组20例，其中高危亚组10例（dft≥5且CSI≥10），低危亚组10例（0〈dft〈5且0〈CSI〈10）。采用高效液相色谱仪分离测定10％蔗糖溶液漱口前、后菌斑液中乳酸、乙酸和丙酸浓度。结果漱口后，有龋组中低危和高危亚组菌斑液乳酸浓度均显著高于漱口前（P〈0．01）。漱口前、后有龋组中高危亚组乳酸浓度差值与dft、CSI呈正相关（r值分别=0．951和0．835，P值均〈0．01）。结论蔗糖溶液漱口前、后乳牙菌斑液乳酸含量的变化与个体龋易感性相关。Objective To investigate the short chain organic acids in dental plaque fluid of children and susceptibility of teeth. Methods 32 children aged 3～5 years with complete primary teeth were recorded by decayed or filled teeth （dft） and Caries Severity Index （CSI） and divided into three groups： caries-free group （dft=0 and CSI=0, n=12）; caries groups （n=20）, including low caries risk group （0〈dft〈5 and 0〈CSI〈10, n =10） and high caries risk group（dft≥5 and CSI≥10, n= 10）. The acids contents, including lactic acid, acetic acid and propionic acid in plaque fluid before and after rinse of 10 % sucrose solution were determined by high performance liquid chromatography. Results In low and high caries risk groups, the lactic acids content after rinse was higher than that rinsed before （P〈0.01）. There was positive correlation between the increment of lactic acid and dft/ CSI in high caries risk group （r 0. 951, P〈0. 01; r=0. 835, P〈0.01）. Conclusions There is correlation between the increment of lactic acid and the individual susceptibility of caries. （Shanghai Med J, 2006, 29：98-100）

关 键 词：乳牙 菌斑液 龋病 有机酸 高效液相色谱 

分 类 号：R788[医药卫生—口腔医学]