山莨菪碱对小鼠热应激的保护作用  

Protective Effects of Anisodamine on Heat Stress Injury in Mice

作　　者：唐文春[1] 张尽廷 徐小波[1] 段永建[2] 

机构地区：[1]河南大学医学院,河南开封475001 [2]河南大学第一附属医院,河南开封475001

出　　处：《工业卫生与职业病》2006年第2期80-82,共3页Industrial Health and Occupational Diseases

摘　　要：目的探讨预先静脉注射山莨菪碱有无预防热应激小鼠诸脏器损伤的作用。方法实验前，山莨菪碱组动物尾静脉注射山莨菪碱（4mg／kg），热应激组和对照组动物静脉注射等量无菌生理盐水。山莨菪碱组和热应激组动物置于38～40℃、50％～60％相对湿度的热环境中，对照组组于18～30℃室温环境中，测量直肠温度、诸脏器组织硫代巴比妥酸反应物（TBARs）含量及血管壁通透性。结果热应激使小鼠直肠温度升高，并使其诸脏器组织TBARs含量及血管壁通透性升高，而山莨菪碱使诸脏器组织TBARs含量及血管壁通透性降低。结论山莨菪碱对热应激小鼠诸脏器的损伤具有保护作用。Objective To study preventive effects of anisodamine on heat - stress damage in mice by prior intravenous injection. Methods Before heat-stress, anisodamine （4 mg/kg） was injected into mice tail vein of anisodamine groups, and in control groups and heat stress groups, equal amount of aseptic physiological saline was intravenously injected. The mice in anisodamine groups and heat-stress groups were placed at an environment temperture of 38～40℃, with 50%～60% relative humidity; the mice in control groups were positioned at an environment temperature of 18～30℃. Their rectal temperature, capillary permeability and TBARs concentrations in organs homogenate of mice were measured. Results Heat-stress made rectal temperature of mice raise and the capillary permeability and TBARs concentrations in organs homogenate rise also. Anisodamine made the capillary permeability and TBARs concentrations lower. Conclusions Anisodamine showed protective effects on the damage in mice suffering from heat-stress.

关 键 词：热应激 血管壁通透性 TBARS 

分 类 号：R363.274[医药卫生—病理学]