腹膜后生殖细胞瘤:对12例患者的临床研究  

Retroperitoneal germ cell tumors: A clinical study of 12 patients

作　　者：De Backer A. Madern G.C. Hazebroek F.W.J. 王经纬 

机构地区：[1]Department of Pediatric Surgery, Academic Hospital, Free University of Brussels, B-1090 Brussels, Belgium

出　　处：《世界核心医学期刊文摘（儿科学分册）》2006年第2期47-48,共2页

摘　　要：Purpose: The aim of the study was to examine the clinical presentation, method(s) of treatment, complications, and results in newborns and infants with retroperitoneal germ cell tumors (GCTs). Methods: A retrospective chart review of all patients treated between 1974 and 2002 for GCT located in the retroperitoneumin 2 institutions identified 12 patients with histologically proven retroperitoneal GCT. Vital data concerning pregnancy and delivery were analyzed. Age at diagnosis and symptoms were recorded, as well as possibly associated anomalies. Data concerning surgical treatment, perioperative and postoperative complications, histological staging, and final outcome were all analyzed. Results: In 3 patients, the diagnosis had been made antenatally between 31 and 35 weeks of gestation. In 1 patient, the diagnosis was made at birth, and in 8 later in life (ages 3, 5, 7, 8, 8, 11, 18, and 24 months). Symptoms in these 8 boys and 4 girls were abdominal distension and a palpable upper abdominal mass, right-sided in 5, left-sided in 5, and central in 2; the tumor was usually big. Associated anomalies were noted in 4 patients and were chromosomal in 3 (Down syndrome in 2 and Klinefelter syndrome in 1). One baby died of uncontrollable bleeding during an emergency operation immediately after traumatic birth. The other 11 infants survived. Four other patients showed serious perioperative complications (1 caval vein tear, 1 choledochal tear, 1 cyst rupture, and 1 esophagogastric tear)which were managed without further consequences. Histologically, 4 tumors were mature teratomas, 6 were immature teratomas (grade I in 4, grade II in 1, and grade II-III in 1), and 2 were malignant yolk sac tumors (YSTs). The patients with YSTs underwent surgical biopsy, followed by chemotherapy and excision of the remaining tumor and of the metastases. No adjuvant treatment was administered in the patients with benign disease. Nine survivors with benign tumor are disease-free between 1 and 30 years after surgery. Two patients with YST have now Purpose： The aim of the study was to examine the clinical presentation, method（s）of treatment, complications, and results in newborns and infants with retroperitoneal germ cell tumors （GCTs）. Methods： A retrospective chart review of all patients treated between 1974 and 2002 for GCT located in the retroperitoneumin 2 institutions identified 12 patients with histologically proven retropefitoneal GCT. Vital data concerning pregnancy and delivery were analyzed. Age at diagnosis and symptoms were recorded, as well as possibly associated anomalies. Data concerning surgical treatment, perioperative and postoperative complications, histological staging, and final outcome were all analyzed. Results： In 3 patients, the diagnosis had been made antenatally between 31 and 35 weeks of gestation. In 1 patient, the diagnosis was made at birth, and in 8 later in life （ages 3, 5, 7, 8, 8, 11, 18, and 24 months） . Symptoms in these 8 boys and 4 girls were abdominal distension and a palpable upper abdominal mass, right-sided in 5, left-sided in 5, and central in 2; the tumor was usually big. Associated anomalies were noted in 4 patients and were chromosomal in 3 （Down syndrome in 2 and Klinefelter syndrome One baby died of uneontrol-

关 键 词：生殖细胞瘤 腹膜后 患者 临床研究 手术后并发症 组织学分类 唐氏综合征 食管撕裂 异常表现 婴儿存活 

分 类 号：R739.41[医药卫生—肿瘤] R735.4[医药卫生—临床医学]