发作性运动诱发性运动障碍患者运动功能的fM RI研究  

Study of paroxysmal kinesigenic dyskinesia with fMRI

作　　者：祝一虹[1] 罗本燕[2] 阮凌翔[2] 王美豪[3] 李建策[3] 翁旭初[1] 陈宜张[1] 

机构地区：[1]浙江大学医学院,浙江杭州310006 [2]浙江大学医学院附属第一医院,浙江杭州310009 [3]温州医学院附属第一医院放射科,浙江温州325000

出　　处：《浙江大学学报（医学版）》2006年第2期189-193,共5页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金项目(30250004;30128005;and30170325);国家基础研究发展规划(973)项目(G1999054000);浙江省卫生厅科研基金项目(2002B019)

摘　　要：目的:比较发作性运动诱发性运动障碍(PKD)患者与正常被试者在运动准备和执行过程中大脑激活差异,尤其是皮层下结构。方法:利用事件相关功能磁共振成像(fMR I)技术,结合运动准备和执行任务刺激,使用AFN I软件的反卷积程序生成激活图。结果:PKD患者在运动准备阶段脑区激活较正常人少,其中基底节无激活。执行阶段,除双侧初级运动皮层,其余脑区激活也较正常人少,但不如准备阶段明显。结论:PKD患者在发作间歇期无论准备或执行运动任务,大脑运动环路均表现异常功能状态。此类运动障碍的发生可能是抑制功能的减弱引起的。Objective： To detect the differences in subcortical structures between patients with paroxysmal kinesigenic dyskinesia （PKD） and normal subjects during movement preparation and execution. Methods： The PKD patients performed a movement task, in which a CUE signal （preparation） indicated the movement sequence prior to the appearance of an imperative GO signal （execution）. Event-related functional magnetic resonance imaging （fMRI） and 3dDeconvolve program of AFNI were used to estimate the hemodynamic response function and to generate activation maps. Results： During movement preparation, the activated brain areas in PKD patients were less than those of normal subject, and there was no activation in basal ganglia in PKD patients. During execution, the activation was also less in PKD patients except in bilateral M1. Conclusion： During intermission, abnormalities of the brain still exist in PKD patients when during preparing or performing movement. The movement circuit in the brain displays an unusual state. The attack may be caused by reducing of inhibition in brain areas.

关 键 词：磁共振成像/方法 运动障碍/并发症 运动准备 运动执行 发作性运动诱发性运动障碍 功能磁共振成像 

分 类 号：R741[医药卫生—神经病学与精神病学]