外消旋药喇叭酸甲酯的制备  

Synthesis of racemic methyl jalapionate

作　　者：朱星枚[1] 陈思莳[1] 杨劲松[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2006年第2期158-160,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:30300434)

摘　　要：目的制备外消旋药喇叭酸甲酯。方法以廉价易得的1,10-癸二醇为原料,经单苄醚化、溴代、格氏反应、乙酰化、氢解脱苄、Jone’s氧化和甲酯化等7步反应,制得外消旋药喇叭酸甲酯。结果以总收率7.2%合成了目标化合物,并经1HNMR1、3CNMR和MS确证其结构。结论所用方法成本低廉,反应条件温和,适于外消旋药喇叭酸甲酯的大量合成。OBJECTIVE To prepare the racemic methyl jalapionate.METHODS The title compound was successfully synthesized by using 1,10- decanediol as the starting material via a seven- steps procedure in an overall yield of 7.2% .RESULTS The structure of title compound was confirmed by ^1HNMR, ^13CNMR and MS. CONCLUSION This method is convenient for work - up, economical and available for large- scale synthesis.

关 键 词：外消旋药喇叭酸甲酯 1 10-癸二醇 合成 

分 类 号：R914.5[医药卫生—药物化学]