新型含硫肿瘤坏死因子类肽抑制剂的合成与活性  

Synthesis and Activity of Novel Sulfur-containing Peptidomimetic Inhibitors of Tumor Necrosis Factor

作　　者：王鼎[1] 张奇涵[1] 许家喜[1] 

机构地区：[1]北京大学化学与分子工程学院生物有机与分子工程教育部重点实验室,北京100871

出　　处：《高等学校化学学报》2006年第4期669-671,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20472005)资助

摘　　要：Tumor necrosis factor is one of the important cell factors,which can regulate pro-imflammatory.On the basis of the known and efficient peptidomimetic inhibitors of tumor necrosis factor as the leading compounds,novel sulfur-containing peptidomimetic inhibitors were designed and synthesized in a convenient and efficient manner.Bioassay results indicate that three of them showed some inhibition activity on sTNF-α secretion in HL-60 cells induced by lipolysaccharide,and two of them showed a good stability and inhibition activity.Tumor necrosis factor is one of the important cell factors, which can regulate pro-imflammatory. On the basis of the known and efficient peptidomimetic inhibitors of tumor necrosis factor as the leading compounds, novel sulfur-containing peptidomimetic inhibitors were designed and synthesized in a convenient and efficient manner. Bioassay results indicate that three of them showed some inhibition activity on sTNF-α secretion in HL-60 cells induced by lipolysaccharide, and two of them showed a good stability and inhibition activity.

关 键 词：肿瘤坏死因子 多肽 类肽抑制剂 

分 类 号：O629[理学—有机化学]