大豆异黄酮加钙和骨胶原对PMOP骨的保护作用  

Protective effect of soy isoflavones combined with calcium and bone collagen on bone quality in postmenopausal osteoporosis

作　　者：许继取[1] 赵要武[1] 朱清华[1] 章锡平[1] 贾文波[1] 孙秀发[1] 刘烈刚[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院营养与食品卫生系,武汉430030

出　　处：《中国公共卫生》2006年第4期425-426,共2页Chinese Journal of Public Health

基　　金：教育部新世纪优秀人才支持计划(NCET-04-0707)

摘　　要：目的探讨大豆异黄酮与钙和骨胶原的共同作用对绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)骨密度及生物力学影响。方法设一假手术组;将去卵巢大鼠分为阴性对照组,高、中、低剂量组和碳酸钙对照组,分别给予基础饲料和不同剂量受试物以及碳酸钙,12周后进行骨密度和生物力学测定。结果受试物能增加骨密度及改善部分骨生物力学性能。结论大豆异黄酮与钙和骨胶原组合的受试物可改善雌激素缺乏所致骨质疏松症的骨质性能。Objective To observe the effect of soy isoflavones combined with calcium and bone collagen on bone mineral density（BMD） and biomecthanics in ovariectomized （OVX）rats. Methods Female rats except sham group were ovariectiomized. ALl rats were administered with different diets for 12 weeks. BMD and indexes of biomechanics were detected in grouped rats including OVX, sham, low dose combination, middle dose combination, high dose combination and calcium carbonate groups. Results The combination could significantly increase the BMD and some indexes of biomechanical in the ovariectomized rats. Co.nclusion The combination can increase the BMD and improve bone biomechanics and benefit postmenopausal osteoporosis（PMOP）.

关 键 词：大豆异黄酮 钙 骨胶原 骨质疏松症 

分 类 号：R151.3[医药卫生—营养与食品卫生学]