5个精神分裂症家系的12个遗传标志分析  

Analysis of 12 genetic markers in 5 schizophrenia families

作　　者：钱伊萍[1] 徐鹤定[1] 武春艳[1] 汪栋祥[1] 张野[1] 王祖承[1] 江三多[1] 

机构地区：[1]上海市精神卫生中心,200030

出　　处：《上海精神医学》2006年第1期10-13,共4页Shanghai Archives of Psychiatry

基　　金：上海市精神疾病临床研究中心资助课题;编号02

摘　　要：目的通过5个精神分裂症同胞对家系的12个遗传标志的检测和分析,探索不同染色体上遗传标志与精神分裂症之间的联系。方法按照美国精神障碍诊断与统计手册第3版修订本的精神分裂症诊断标准,选择5个同胞对精神分裂症家系,采用PCR-RFLP、小卫星和微卫星DNA的Amp- FLP技术,观察12个遗传标志MAOACA、MAOBTG、MAOBI2、DXS7、D6S296、D6S274、D6S470、D6S260、 SCA1、D9S175、DAT1和APOE的分布。结果从各遗传标志的等位基因在家系成员中分布及复等位基因传递不平衡检验(TDT),未见明显关联现象。结论12个国内、外资料曾表明与精神分裂症有关联的遗传标志,经5个同胞对精神分裂症家系成员中检测和分析,未见明显的连锁和关联。Objective： To explore the association between the 12 genetic markers on different chromosomes and schizophrenia in 5 families. Methods： Patients who fulfilled the criteria for schizophrenia according to DSM -Ⅲ and their siblings from 5 families were selected. 12 genetic markers of MAOACA, MAOBTG,MAOBI2 ,DXS7, D6S296 ,D6S274 ,D6S470,D6S260, SCA1, D9S175, DAT1和APOE were tested by PCR -RFLP and Amp -FLP and the transmission disequilibrium test （TDT） analyzed. Results ：There was no association between the 12 genetic markers and schizophrenia. Conclusion： 12 genetic markers which were associated with schizophrenia were tested in 5 schizophrenic families and there was no positive association and linkage with schizophrenia.

关 键 词：精神分裂症 家系研究 多态性 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]