甲磺酸倍他斯汀的合成  

Synthesis of betahistine mesilate

作　　者：林迎明[1] 曲有乐[2] 周淑晶[1] 

机构地区：[1]佳木斯大学化学与药学院,黑龙江佳木斯154007 [2]浙江海洋学院,浙江定海316000

出　　处：《黑龙江医药科学》2006年第2期35-35,共1页Heilongjiang Medicine and Pharmacy

摘　　要：目的:合成甲磺酸倍他斯汀。方法:以2-乙烯基吡啶为原料,经加成,成盐两步反应合成甲磺酸倍他斯汀。结果:合成了甲磺酸倍他斯汀,总收率为72%。结论:本方法操作简便,适合工业化生产。Objective： To synthesize betahistine mesilate. Method： Betahistine mesilate was prepared from 2- vinylpyridine by a 2- step process of addition and salification. Results： The total yield of betahistine mesilate was 72%. Conclusion ：The method is simple, suitable for its industrialized production.

关 键 词：甲磺酸倍他斯汀 合成 

分 类 号：R914.5[医药卫生—药物化学]