以肝星状细胞为靶标探讨牛磺酸对门脉高压的影响  

Effect of taurine on hepatic stellate cell of portal hypertension

作　　者：梁健[1] 邓鑫[1] 吴金玉[2] 杨光业[3] 黄仁彬[4] 

机构地区：[1]广西中医学院附属瑞康医院,南宁530011 [2]广西中医学院第一附属医院,南宁530023 [3]广西医学情报研究所,南宁530023 [4]广西医科大学,南宁530021

出　　处：《广西医学》2006年第2期182-184,共3页Guangxi Medical Journal

基　　金：广西壮族自治区自然科学基金资助项目(合同号:0144016)

摘　　要：目的以肝星状细胞(HSC)为靶标探讨牛磺酸对门脉高压的影响。方法胶原晶格收缩法观察其对HSC-T6细胞收缩的影响,硝酸还原酶法测定一氧化氮(NO),化学比色法测定一氧化氮合酶(NOS)活性。结果牛磺酸能显著抑制HSC-T6收缩(P<0·05或P<0·01),抑制作用与剂量呈依赖关系;牛磺酸能增加HSC分泌NO和增强NOS的活性。结论牛磺酸具有一定的降低门脉高压的作用。Objective To investigate the effect of taurine at hepatic stellate（HSC） on portal hypertension.Methods HSC-T6 cells contraction were studied by the contraction collagen lattice. The levels of NO, activity of nitric oxide synthase（NOS） were detected by nitric reductase and colorimetry. Results Taurlne can inhibit the contraction of HSC- T6 cells （P〈0.05 or P〈0.01）as direct relation of concentrations, taurine can inhibited the secretion of NO and accivity of iNOS.Conclusion Taurine can reduce portal hyension.

关 键 词：牛磺酸 HSC NO NOS 

分 类 号：R917[医药卫生—药物分析学] R575.21[医药卫生—药学]