北京万寿路地区319例男性AR基因(CAG)n重复序列多态的研究  

Study of AR Gene (CAG)n Repeat Polymorphism in 319 male Residents of Wanshoulu District,Beijing

作　　者：楚新梅[1] 李小鹰[1] 梁春红[1] 叶玲[1] 刘建伟[1] 

机构地区：[1]中国人民解放军总医院老年心内科,北京市复兴路28号100853

出　　处：《中国分子心脏病学杂志》2006年第1期27-29,共3页Molecular Cardiology of China

基　　金：全军十五面上课题(01AM301)

摘　　要：目的研究自然人群中老年男性雄激素受体(AR)基因CAG重复序列多态。方法使用DNA测序方法对319例老年男性AR基因外显子1 NH2端转录调节区内CAG重复序列长度进行测定。结果男性雄激素受体基因CAG重复数最短为8,最长为35。CAG重复数平均值为(22．70 ±3．66)。CAG重复数分布频率最多的为21(13．8％),22(15．7％),23(13．5％)和24(10．3％),共占 53．3％。结论自然人群中老年男性雄激素受体基因CAG重复序列呈现多态性,多数集中在21- 24,为进一步研究AR基因变异与疾病的关系提供依据。Objective To analyze CAG length polymorphism of androgen receptor gene in oldermen. Methods A study was performed in healthy subjects, which were randomly selected 319 males, whoaged from 60 - 92 years old in Wanshoulu District, Beijing. DNA sequencing of the CAG repeat from whichthe N-terminal domain of the first exon of the AR gene, were analyzed by applied Biosystems 3730xl DNAAnalyzer. Results The AR allele length ranged from 8 - 35 CAG repeat in 319 older men. Average of CAGrepeat was 22.70 ±3.66. The most repeat frequency come to 53.3%, which were 21 （ 13.8% ）, 22（ 15.7% ）, 23 （ 13.5% ） and 24（ 10.3% ）. Conclusions Androgen receptor gene CAG length showed polymorphism in older men, most of the CAG length focused on 21 - 24. This study offered the basic data on relationship for AR gene and disease.

关 键 词：雄激素受体基因 CAG重复序列多态 男性 

分 类 号：R394[医药卫生—医学遗传学]