布加综合征与凝血因子V Leiden及凝血酶原基因G20210A突变的关系研究  

A study on the correlations between pathogenesis of Budd-Chiari syndrome and Factor V Leiden and Factor Ⅱ G20210A mutations

作　　者：林国领[1] 许培钦[2] 齐华[3] 连建华[3] 郑红[3] 党晓卫[2] 

机构地区：[1]复旦大学附属中山医院肝癌研究所,上海200032 [2]郑州大学第一附属医院普外科 [3]郑州大学基础医学院细胞生物学及医学遗传学教研室

出　　处：《中华普通外科杂志》2006年第4期275-277,共3页Chinese Journal of General Surgery

摘　　要：目的研究布加综合征(BCS)患者凝血因子V Leiden突变(FVLeiden)及凝血酶原基因G20210A突变(FⅡG20210A)的情况及其与BCS发病的相关性。方法利用聚合酶链反应-限制性片段长度多态性分析法(PCR-RFLP)对比检测49例BCS患者及70例健康对照者FVLeiden及 FⅡG20210A突变情况。结果 45例中国汉族散发性BCS患者、两对家族性BCS患者及70例汉族健康对照个体未发现有F V Leiden及F ⅡG20210A突变。结论我国汉族BCS患者未发生 FVLeiden及FⅡG20210A突变,BCS的发病与FVLeiden及FⅡG20210A突变无相关性。Objective To explore Factor Ⅴ Leiden and Factor Ⅱ G20210A mutations in Budd- Chiari syndrome （BCS）. Methods Forty-nine BCS patients including two pairs of siblings and seventy heathy controls were examined by using polymerase chain-restriction fragment length polymorphisms （PCR-RFLP） for F Ⅴ Leiden and F Ⅱ G20210A mutations. Results The F Ⅴ Leiden and F Ⅱ G20210A mutations were not detected in 45 sporadic BCS patients and two pairs of familial BCS patients and 70 controls. Conclusion There is no F Ⅴ Leiden and F Ⅱ G20210A mutations in Chinese BCS patients. The pathogenesis of BCS is not correlated with FⅤ Leiden and F Ⅱ G20210A mutations.

关 键 词：高血压 门静脉 凝血酶原 因子Ⅴ 基因突变 

分 类 号：R575[医药卫生—消化系统]