相转移催化剂-β-环糊精催化下苯基甘氨酸选择性合成  

Selective Synthesis of Phenylglycine in the Presence of Phase Transfer Catalyst-β-Cyclodextrin Binary System

作　　者：周成合[1] 袁德其[1] 谢如刚[1] 

机构地区：[1]四川大学化学系,成都610064

出　　处：《应用化学》1996年第3期46-49,共4页Chinese Journal of Applied Chemistry

基　　金：国家自然科学;国家教委博士基金

摘　　要：在相转移催化剂(PTC)和β-环糊精(β-CD)混合催化剂存在下,由苯甲醛、氯仿、氢氧化钾和氨水一锅合成了苯基甘氨酸,不同类型 PTC-β-CD 均有较好的催化作用,且比单独的 PTC 或β-CD 有更显著的催化效果.A one-pot selective synthesis of phenylglycine with high yield from benzaldehyde, chloroform,potassium hydroxide and ammonia in the presence of phase-transfer catalyst (PTC)and β-cyclodextrin(β-CD)binary catalyst system has been studied.Results obtained are far superior to that of other similar methods.The data show that PTC β-CD is a more efficient catalyst than either PTC or β-CD alone,and both cationic and nonionie PTC-β-CD can enhance the production of phenylglycine with good yields and selectivities.A preliminary mechanism is also discussed.

关 键 词：苯基甘氨酸 Β-环糊精 相转移催化剂 选择性 合成 

分 类 号：O629.71[理学—有机化学] O643.36[理学—化学]