广州市某小学学习障碍儿童碘营养状况调查  

Study on iodine nutrition in schoolchildren with learning disorders in Guangzhou

作　　者：梁小红[1] 王庆雄[2] 毋福海[1] 王秀霞[1] 欧柏新[1] 李莹涛[1] 李静[1] 林宝妮[1] 

机构地区：[1]广东药学院公共卫生学院,广州510310 [2]中山大学公共卫生学院妇幼卫生系

出　　处：《中国地方病学杂志》2006年第3期300-301,共2页Chinese Jouranl of Endemiology

基　　金：广东省卫生厅立项课题(A2001293)

摘　　要：目的了解广州市某小学学习障碍(LD)儿童碘营养状况。方法用砷-铈接触法测定尿碘,用放射免疫分析法(RIA)测定静脉血清T4,用免疫放射分析法(IRMA)测定静脉血清TSH。用学习困难儿童筛查量表结合平时成绩选出ID组及对照组。用瑞文智力测验测定智商。结果学习障碍组尿碘中位数为216．6 μg／L,<100μg／L者占22．8％;对照组尿碘中位数为247．9μg／L,<100μg／L者占3．7％。两组尿碘中位数差异无统计学意义(Z=-1．37．P>0．05),但两组尿碘值<100μg/L与≥100μg/L的人数构成差异有统计学意义 (X2=8．65,P<0．01)。两组血清T4均在正常范围(54-174 nmol／L)内。学习障碍组血清TSH(中位数2．2 mU／L)>3．1 mU／L者占18．8％;对照组血清TSH(中位数1．9 mU／L)>3．1 mU／L者占12．9％,两组TSH>3．1 mU/L与<3．1 mU／L人数构成差异无统计学意义(X2=3．85,P>0．05)。学习障碍组智商为97．8±13．1;对照组智商为117．4±1．8;两组智商的差异有统计学意义(t=8．26,P<0．01)。结论广州市学习障碍儿童多数碘营养状况良好;学习障碍组尿碘值<100 μg／L者较对照组多,提示学习障碍儿童部分人缺碘,缺碘与学习障碍的关系,有待进一步探讨。学习障碍儿童智商较对照组低。Objective To investigate the nutritional status of iodine in children with learning disabilities （LD） in Guangzhou. Methods The urinary iodine was measured with colorimetic ceric-arsenic assay. Content of T4 in serum was determined by radioimmunoassay （RIA）. TSH in serum was determined by immunoradiometric assay （IRMA）. Children with learning disabilities were screened with PRS （The Pupil Rating Scale Revised-Screening for LD） and school report, and their intelligence was examined with Combined Raven＇s Test. Results The median of urinary iodine in children with learning disabilities and control group was 216.6 μg/L and 247.9 μg/L respectively. The median of urinary iodine showed no significant difference between them （Z = - 1.37,P 〉 0.05）. The ratio of children with urinary iodine 〈 100 μg/L was 22.8% and 3.7% in the LD and control group respectively, no significant difference was seen （χ^2 = 8.65,P 〈 0.01 ）. The average T4 level in two groups were within 54 - 174 nmol/L （recommended rang）. The ratio of children with TSH 〉 3.1 mU/L in LD group was 18.8% and was 12.9% in control group, there was no significant difference between them（χ^2 = 3.85,P 〉 0.05）. Intelligence in LD group is lower than that in the control group （t = 8.26,P 〈 0.01 ）. Conclusions Most of the children with learning disabilities in Guangzhou have good nutritional status of iodine, but they have lower urinary iodine than the controls. Intelligence of LD group is lower than that of the control group. The relations between iodine deficiency and learning disabilities need further research.

关 键 词：学习障碍 碘 甲状腺素 促甲状腺激素 智力 

分 类 号：R749.94[医药卫生—神经病学与精神病学]