硫辛酸对高脂日粮大鼠脂类代谢和抗氧化能力的影响  

Effects of Lipoic Acid on Blood Lipid Metabolism and Antioxidation Capability of High-fat Diet Fed Rats

作　　者：李安林[1] 施用晖[1] 岳鹏[1] 朱建津[1] 乐国伟[1] 

机构地区：[1]江南大学食品学院食品科学与安全教育部重点实验室,江苏无锡214036

出　　处：《食品科学》2006年第5期242-245,共4页Food Science

基　　金：国家自然科学基金项目(30571347)

摘　　要：实验研究了硫辛酸(LipoicAcid,LA)对饲喂高脂日粮大鼠脂肪代谢及其抗氧化能力的影响。24只SD大鼠分成3组,分别是常规日粮对照组,高脂日粮组和高脂日粮+LA(0.1%)组。结果表明饲喂高脂日粮可导致大鼠实验性高脂血症,与高脂模型组相比,日粮中添加LA可显著降低大鼠血清TG、TC、LDL-C的含量,使动脉粥样硬化指数降低(p<0.05),显著增加血清HDL-C的含量(p<0.05),显著提高血清LPL和HL的活性;使血清和组织T-AOC、SOD活性、GSH含量显著上升(p<0.05),MDA含量显著降低(p<0.05)。说明添加LA对饲喂高脂日粮大鼠的血脂水平有明显的调节作用,可有效抑制脂质过氧化,预防动脉粥样硬化的发生。In this work the effects of Lipoic acid（LA） on blood lipid metabolism and antioxidation capability of rats fed with high-fat diet were explored. 24SD rats were divided into 3 groups： control group,high-fat group and LA （0.1%）group. Results showed that high-fat diet can cause hyperlipidemia.The content of TG, TC, LDL-C in serum were decreased significantly in LA group while the content of HDL-C in serum increased significantly.In comparison with high-fat group, both activities of LPL, HL, SOD in serum and the content of T-AOC, GSH, MDA in both serum and tissue increased significantly in LA group. Moreover, LA could decrease atherosclerotic index（AI）. Conclusions： LA has the function of reducing blood lipid and anti-lipid peroxidation, and preventing from atherosclerosis.

关 键 词：硫辛酸 高脂血症 脂质过氧化 动脉粥样硬化 

分 类 号：TS202.3[轻工技术与工程—食品科学] TS201.4[轻工技术与工程—食品科学与工程]