High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia  

作　　者：Si-yuan PAN Rong YANG Yi-fan nAN Hang DONG Xu-dong FENG Na LI Wei GENG Kam-ming KO 

机构地区：[1]Department of Pharmacology, Beijing University of Chinese Medicine, Beijing 100029, China [2]Department of Biochemistry, Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China

出　　处：《Acta Pharmacologica Sinica》2006年第6期673-678,共6页中国药理学报（英文版）

基　　金：Project supported by a grant from the Natural Science Foundation of Beijing City(№7022017).

摘　　要：Aim： To investigate the effects of bifendate on serum and hepatic lipids level in rabbits and mice. Methods： Animals were administered bifendate [powdered pill suspended in 0.5% sodium carboxymethylcellulose （CMC）] at increasing doses （0.25-1 g/kg, ig）. Blood lipid and apolipoprotein levels were measured using commercially available assay kits. Results： The treatment of rabbits with a single dose of bifendate （0.3 g/kg） caused a time-dependent and biphasic change in serum triglyceride （TG） levels, with the value reaching a maximum （3-fold increase compared to the baseline value） between 24 and 36 h post-dosing. When mice were orally treated with bifendate （0.25-1 g/kg）, serum TG levels increased by 39%-76% and 14%-39% at 24 and 48 h post-dosing, respectively. When given at daily doses of 0.25 and 1 g/kg for 4 d, bifendate increased serum TG levels （56%- 79%）, with concomitant elevations in apolipoprotein A-I and apolipoprotein B levels at 24 h after the last dosing. TG levels were also increased （11%-43%） in liver samples of mice receiving single or multiple doses of bifendate. However, bifendate treatment caused slight reductions in serum and hepatic total cholesterol levels （9%-13%）. The hypertriglyceridemia induced by bifendate was ameliorated by fenofibrate but not inositol nicotinate treatment in mice. Conclusion： The findings suggest that bifendate treatment at high oral doses can cause an acute elevation in serum and hepatic TG levels.Aim： To investigate the effects of bifendate on serum and hepatic lipids level in rabbits and mice. Methods： Animals were administered bifendate [powdered pill suspended in 0.5% sodium carboxymethylcellulose （CMC）] at increasing doses （0.25-1 g/kg, ig）. Blood lipid and apolipoprotein levels were measured using commercially available assay kits. Results： The treatment of rabbits with a single dose of bifendate （0.3 g/kg） caused a time-dependent and biphasic change in serum triglyceride （TG） levels, with the value reaching a maximum （3-fold increase compared to the baseline value） between 24 and 36 h post-dosing. When mice were orally treated with bifendate （0.25-1 g/kg）, serum TG levels increased by 39%-76% and 14%-39% at 24 and 48 h post-dosing, respectively. When given at daily doses of 0.25 and 1 g/kg for 4 d, bifendate increased serum TG levels （56%- 79%）, with concomitant elevations in apolipoprotein A-I and apolipoprotein B levels at 24 h after the last dosing. TG levels were also increased （11%-43%） in liver samples of mice receiving single or multiple doses of bifendate. However, bifendate treatment caused slight reductions in serum and hepatic total cholesterol levels （9%-13%）. The hypertriglyceridemia induced by bifendate was ameliorated by fenofibrate but not inositol nicotinate treatment in mice. Conclusion： The findings suggest that bifendate treatment at high oral doses can cause an acute elevation in serum and hepatic TG levels.

关 键 词：BIFENDATE FENOFIBRATE inositol nicotinate TRIGLYCERIDES total cholesterol acute hypertriglyceridemia 

分 类 号：R589[医药卫生—内分泌]