BIFENDATE

作品数：4被引量：9H指数：2
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相关领域：医药卫生更多>>
相关期刊：《Acta Pharmacologica Sinica》《Acta Pharmaceutica Sinica B》更多>>
相关基金：国家自然科学基金北京市自然科学基金更多>>
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A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression被引量：1
《Acta Pharmacologica Sinica》2020年第5期661-669,共9页Na Zhang Shuang-shuang Zhao Yi-xuan Zhang Yu-cheng Wang Rong-guang Shao Ju-xian Wang Hong-wei He 
the Fundamental Research Funds for the Central Universities(3332019083);the National Natural Science Foundation of China(Nos.81673497,81903695);the CAMS Innovation Fund for Medical Sciences(No.2019-I2M-1–001);the National Science&Technology Major Project"Key New Drug Creation and Manufacturing Program",China(No.2019ZX09201001).
Chronic tissue injury with fibrosis results in the disruption of tissue architecture,organ dysfunction,and eventual organ failure.Therefore,the development of effective antifibrotic drugs is urgently required.IMB-S7 i...
关键词：BIFENDATE IMB-S7 hepaticfibrosis integrinαv SP1 TGF-β/Smad pathway bile duct ligation LX2 cells 
Study on four polymorphs of bifendate based on X-ray crystallography被引量：2
《Acta Pharmaceutica Sinica B》2016年第3期234-242,共9页Jinju Nie Dezhi Yang Kun Hu Yang Lu 
Ministry of Science and Technology of the People's Republic of China for the National Science(Grant No.2012ZX09301002-001-013)
Bifendate, a synthetic anti-hepatitis drug, exhibits polycrystalline mode phenomena with 2polymorphs reported(forms A and B). Single crystals of the known crystalline form B and 3 new crystallosolvates involving bifen...
关键词：BIFENDATE POLYMORPHISM Solvatomorphism SINGLE-CRYSTAL structure Thermal analysis FT-IR 
Effect of bifendate on the pharmacokinetics of cyclosporine in relation to the CYP3A4＊18B genotype in healthy subjects被引量：6
《Acta Pharmacologica Sinica》2009年第4期478-484,共7页Yong ZENG Yi-jing HE Fu-yuan HE Lan FAN Hong-hao ZHOU 
This work was supported by research grants from the National Natural Science Foundation of China （No 30672497）, the China Medical Board of New York （grant No 01-755）, and the Hunan Health Research Foundation of Traditional Chinese Medicine （grant No 204041）.
Aim： To evaluate the potential drug-drug interactions between bifendate and cyclosporine, a substrate of CYP3A4, in relation to different CYP3A4＊18B genotype groups. Methods： Eighteen unrelated healthy subjects （s...
关键词：BIFENDATE CYCLOSPORINE PHARMACOKINETICS CYP3A4＊18B 
High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia
《Acta Pharmacologica Sinica》2006年第6期673-678,共6页Si-yuan PAN Rong YANG Yi-fan nAN Hang DONG Xu-dong FENG Na LI Wei GENG Kam-ming KO 
Project supported by a grant from the Natural Science Foundation of Beijing City(№7022017).
Aim： To investigate the effects of bifendate on serum and hepatic lipids level in rabbits and mice. Methods： Animals were administered bifendate [powdered pill suspended in 0.5% sodium carboxymethylcellulose （CMC）...
关键词：BIFENDATE FENOFIBRATE inositol nicotinate TRIGLYCERIDES total cholesterol acute hypertriglyceridemia 
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