转移抑制基因nm23在恶性黑素瘤中的表达  

Expression of Matastatic Suppressor Gene nm23 in Human Malignant Melanoma

作　　者：刘丹亚[1] 苏宝山[2] 徐汉卿[1] 陈学民[3] 

机构地区：[1]西安医科大学第二附属医院皮肤科,710004 [2]西安医科大学第二附属医院病理科,710004 [3]西安医科大学第一附属医院内科,710004

出　　处：《中华皮肤科杂志》1996年第1期45-47,共3页Chinese Journal of Dermatology

摘　　要：为了研究 nm23/二磷酸核苷激酶(NDPK)表达与人恶性黑素瘤(恶黑)转移潜力的关系,我们用免疫组化技术研究了恶黑组织中 nm23基因的表达,以及表达程度与组织病理、细胞 DNA 含量、增殖指数和临床预后的相关性。结果发现 nm23/NDPK 在转移性恶黑及原发性恶黑伴淋巴结转移时表达减低。其表达程度与 DNA 含量及增殖指数呈负相关,而与临床分期无关。另外,nm23/NDPK 表达程度高者生存时间较表达低者长。结果提示:nm23基因表达对恶黑的转移具有负调控作用,其表达低者意味着肿瘤组织具有高转移潜能。nm23/NDPK 的作用机理可能是通过影响细胞微管的聚合而发挥作用。The present study was conducted to clarify the association of nm23 expression with metastatic potential in human malignant melanoma(MM).The expression of am23 gene was studied us- ing immunohistochemical method in human malignant melanoma,and association of extent of expression of nm23/NDPK with histopathological classification,DNA contents and prognosis was analyzed.The expression of nm23/NDPK in patients with metastatic malignant melanoma and primary malignant melanoma with lymph node metastasis was significantly reduced than in patients without metastasis. The intensity of nm23/NDPK was negatively correlated with DNA contents and proliferation index,but not correlated with histopathological classification of tumor.Additionally patients with increased expres- sion of nm23/NDPK may have longer survival time than patients with reduced expression.Our results implicated that the expression of nm23 gene may suppress the metastasis of malignant melanoma.The tumor With low nm23/NDPK level indicates a high metastatic potential.The mechanism of action of nm23 may modulate the polymerization of cellular microtuble in tumor cells.

关 键 词：黑色素瘤 恶性 NM23基因 转移抑制基因 基因表达 

分 类 号：R739.5[医药卫生—肿瘤]