UVB-irradiated human keratinocytes and interleukin-1■ indirectly increase MAP kinase/AP-1 activation and MMP-1 production in UVA-irradiated dermal fibroblasts  

作　　者：WANG Xiao-yong BI Zhi-gang 

机构地区：[1]Department of Dermatology, First Affiliated Hospital of NanjingMedical University, Nanjing 210029, China

出　　处：《Chinese Medical Journal》2006年第10期827-831,共5页中华医学杂志（英文版）

基　　金：This research was supported by a grant from National Natural Science Foundation of China (No. 30271195)

摘　　要：Background Solar ultraviolet （UV） irradiation induces the production of matrix metalloproteinases （MMPs） by activating cellular signalling transduction pathways. MMPs are responsible for the degradation and/or inhibition of synthesis of collagenous extracellular matrix in connective tissues. We mimicked the action of environmental ultraviolet on skin and investigated the effects of UVB-irradiated human keratinocytes HaCaT and IL-1α on mitogen activated protein （MAP） kinase activation, c-Jun and c-Fos （AP- 1 is composed of Jun and Fos proteins） mRNA expression and MMP-1 production in UVA-irradiated dermal fibroblasts.Background Solar ultraviolet （UV） irradiation induces the production of matrix metalloproteinases （MMPs） by activating cellular signalling transduction pathways. MMPs are responsible for the degradation and/or inhibition of synthesis of collagenous extracellular matrix in connective tissues. We mimicked the action of environmental ultraviolet on skin and investigated the effects of UVB-irradiated human keratinocytes HaCaT and IL-1α on mitogen activated protein （MAP） kinase activation, c-Jun and c-Fos （AP- 1 is composed of Jun and Fos proteins） mRNA expression and MMP-1 production in UVA-irradiated dermal fibroblasts.

关 键 词：ultraviolet KERATINOCYTES FIBROBLASTS INTERLEUKIN-1Α matrix metalloproteinase-1 

分 类 号：R75[医药卫生—皮肤病学与性病学]