牛膝多糖对脑外伤大鼠脑组织中ROS、XOD和MPO影响的实验研究  

THE EFFECT OF ACHYANTHIS POLYSACCHARIDES ON ROS AND XOD AND MPO IN THE RATS BRAIN WITH CEREBRAL TRAUMA

作　　者：盛延良[1] 王洪伟[2] 孟庆媛[1] 吕秀芳[2] 

机构地区：[1]佳木斯大学基础医学院病理教研室,154000 [2]牡丹江医学院

出　　处：《牡丹江医学院学报》2006年第4期6-8,共3页Journal of Mudanjiang Medical University

摘　　要：目的:探讨牛膝多糖对实验性脑外伤大鼠脑组织中氧化应激指标ROS、XOD和MPO的影响,以寻求治疗和预防脑外伤后继发性改变的新方法。方法:建立脑外伤大鼠模型,分别在外伤后不同时相观察正常组,模型组,牛膝多糖高、中、低剂量治疗组大鼠脑组织中ROS,XOD和MPO的变化。结果:在不同时相牛膝多糖治疗组大鼠脑组织中ROS,XOD和MPO活性显著低于模型组(P<0.05),高、中剂量治疗组与低剂量治疗组相比有显著性差异(P<0.05)。结论:牛膝多糖能够降低脑组织中ROS、XOD和MPO活性,提高大鼠的抗氧化能力,从而延缓和防治脑外伤发展,故可用于治疗和预防脑外伤后的二次损伤和多次损伤。Objective ：To investigate the effect of achyranthis polysaccharides on the influence of oxidative stress of rats with cerebral trauma, and to find the new way to treat and prevent it＇s second change. Methods：After making the cerebral trauma model ,we observe the change of ROS and XOD and MPO in the rats＇brain tissue at different time in each group. Results：At different time , the activity of ROS and XOD and MPO in the operated groups rats＇brain tissue is remarkably lower than the model group rats（P〈0.05） ,there was significant difference bewteen the high - dose , middle -dose groups rats and low -dose group rats. Conclusion：Achyranthis polysaccharides can decrease the activity of ROS and XOD and MPO,and can elevate the ability of antioxidation. So it can delay and prevent the development of cerebral trauma and can be used toprevent and cure secondary disease and multiple affection.

关 键 词：牛膝多糖 脑外伤 ROS XOD MPO 

分 类 号：R361[医药卫生—病理学]