生物节律在常染色体显性遗传夜间额叶癫择时用药的意义  

Significance of Biological Rhythm on Selective Nocte Treatment on Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

作　　者：胡家胜[1] 刘智胜[1] 王芳琳[1] 吴小满[2] 

机构地区：[1]武汉市儿童医院神经内科,武汉430016 [2]武汉市普爱医院儿科,武汉430030

出　　处：《实用儿科临床杂志》2006年第12期769-770,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨卡马西平睡前一次用药治疗常染色体显性遗传夜间额叶癫痫（ADNFLE）患儿的疗效及其与生物节律的关系。方法ADNFLE患儿36例随机分成常规治疗组19例，予卡马西平片10-25mg／（kg·d），分3次口服；择时治疗组17例，卡马西平片5～10mg／（kg·d），睡前1次口服。患儿均随访3年。结果常规治疗组和择时治疗组的总有效率分别为74％和71％，两组无明显差异（P〉0．05）。择时治疗组呕吐、头晕、乏力、皮疹等不良反应少于常规治疗组（P〈0．05）。结论卡马西平择时治疗（睡前顿服）与常规治疗ADNFLE的疗效相近，生物节律可能呈现于ADNFLE睡眠发作中。Objective To study the effect of autosomal dominant nocturnal frontal lobe epilepsy （ADNFLE） with carbamazepine belug taken at a draught before sleep and its relationship with biological rhythm. Methods Thirty - six patients with ADNFLE were divided into 2 groups： the treatment group with 17 patients took carbamazepine 5 - 10 mg/（kg·d） at night ,and the control group in which the other patients were treated with carbamazepine at the dose of 10 25 mg/（kg· d） in three times. All patients were followed up for 3 years. Results The total effective rate of treatment and control group was 74 % and 71%, respectively （ P 〉 0.05）. The adverse effect of treatment group was significantly less than control group（P〈 0.05）. Conclusions The effect of selective therapy is similar to normal therapy in carbamazepine therapy of children with ADNFLE, and the biological rhythm may affect attack of ADNFLE in sleep period. The dosage of carbamazepine is smaller and its advers effect is less in select treatment of ADNFLE.

关 键 词：常染色体 额叶癫痈 生物周期性 卡马西平 

分 类 号：R742.1[医药卫生—神经病学与精神病学]