多巴胺转运体基因多态性与强迫症的关联  

Association analysis between polymorphism of dopamine transporter variable number tandem repeat and obsessive-compulsive disorder

作　　者：周云飞[1] 张亚林[2] 胡纪泽[1] 刘妹 刘铁榜[1] 吴怀安[1] 赵幸福[2] 

机构地区：[1]深圳市康宁医院,深圳518003 [2]中南大学湘雅二医院精神卫生研究所 [3]深圳市人民医院

出　　处：《中国行为医学科学》2006年第7期586-587,共2页Chinese Journal of Behavioral Medical Science

基　　金：深圳市科技计划资助项目(JH200505180193A)

摘　　要：目的探索汉族人群中多巴胺转运体可变数目串联重复区基因多态性与强迫症的发病关系。方法对强迫症和正常对照组分别采用聚合酶链反应扩增片断长度多态技术测定基因型。结果测到4种等位基因8,9,10,11。强迫症患者与正常对照组DATVNTR的等位基因及基因型频率差异无显著性(2=4.012,P=0.581;2=4.311,P=0.334)。结论在汉族人群中,DATVNTR基因多态性基因型和等位基因与强迫症无明显关联。Objective To explore the association between polymorphism of dopamine transporter variable number tandem repeat （DATVNTR） and obsessive-compulsive disorder （OCD） in the Han nationalitve. Methods OCD patients and normal controls were included in this study. The subjects were genotyped directly for the 5-HTTLPR with polymerase chain reaction amplification fragment length polymorphism techniques. Results There were no significant differences between OCD patients and normal controls in the frequencies of genotype and allele for DATVNTR（x^2 =4. 012, P=0. 581;x^2 =4. 311, P= 0. 334）. Conclusion There were no significant association in DATVNTR gene polymorphism between OCD patients and normal controls.

关 键 词：强迫症 多巴胺转运体 可变数目串联重复序列 基因多态性 

分 类 号：R749.7[医药卫生—神经病学与精神病学]