脂蛋白脂酶Hind Ⅲ基因多态性与动脉硬化性脑梗死的关系  

Associations between Hind Ⅲ gene polymorphism of lipoprotein lipase and atherosclerotic cerebral infarction

作　　者：徐恩[1] 官国东[1] 刘晓蓉[1] 陈盛强[1] 

机构地区：[1]广州医学院第二附属医院神经内科神经科学研究所,510260

出　　处：《中华神经科杂志》2006年第6期383-387,共5页Chinese Journal of Neurology

基　　金：广东省自然科学基金(31776)

摘　　要：目的研究脂蛋白脂酶HindⅢ基因多态性与动脉硬化性脑梗死发病的关系及其对血脂、颈动脉斑块的影响。方法选择166例动脉硬化性脑梗死患者,采用聚合酶链反应限制性片段长度多态性分析检测脂蛋白脂酶的HindⅢ基因多态性,颈动脉超声多普勒检查颈总动脉内膜中层厚度和颈动脉斑块,并与72名健康对照比较。结果在脑梗死组中H+H+基因型频率和H+等位基因频率明显高于对照组(OR=2.267,P=0.004;OR=1.903,P=0.004),而血脂水平、颈总动脉内膜中层厚度、颈动脉斑块分级与对照组比较差异无统计学意义。结论脂蛋白脂酶的HindⅢ基因多态性与脑梗死的关系密切,H+H+基因型可能是脑梗死的危险因素。Objective To study the associations between Hind Ⅲ gene polymorphism of LPL and atherosclerotic cerebral infarction and to investigate the effect of Hind Ⅲ gene polymorphism on plasma lipids, carotid intima-media thickness （IMT） and carotid artery plaque （CAP） in patients with atherosclerotic cerebral infarction. Methods PCR-RFLP technique was used to detect Hind Ⅲ gene polymorphism of lipoprotein lipase gene in 166 patients with atherosclerotic cerebral infarction （CI group） and 72 healthy subjects （control group）. Carotid IMT and CAP were measured with carotid color ultrasonographic Doppler for the patients and the controls. Results The frequencies of the H ＋ H ＋ genotypes and H ＋ allele gene in CI group were significantly higher than those in control group （ OR = 2.267,P=0.004 and OR = 1.903, P =0.004）. There was no statistical difference of plasma lipids and IMT between CI and control groups. Conclusions The polymorphism of LPL HindⅢ gene is associated with CI. H ＋ H ＋ genotype may be a risk factor of CI.

关 键 词：颅内动脉硬化 脑梗塞 脂蛋白脂酶 多态现象(遗传学) 

分 类 号：R743.33[医药卫生—神经病学与精神病学]