普伐他汀联合阿司匹林治疗急性脑梗死的临床研究  

Clinical Study of Pravastatin Combined with Aspirin in Patients with Acute Cerebral Infarction

作　　者：郭正良[1] 傅毅[1] 辛晓瑜[1] 曾丽莉[1] 沈介明[1] 刘建荣[1] 陈生弟[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院神经科,200025

出　　处：《中国临床神经科学》2006年第4期354-357,共4页Chinese Journal of Clinical Neurosciences

基　　金：上海市科学技术委员会重大科研项目基金(03DZ19702)资助

摘　　要：目的:探讨普伐他汀联合阿司匹林治疗急性脑梗死的临床疗效和预后。方法:115例急性脑梗死患者,随机分为普伐他汀联合阿司匹林治疗组(57例)和单用阿司匹林治疗组(58例),随访6个月,比较两组治疗前、后的美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力指数(BI)、改良的Rankin(mRS)评分和简易智能量表(MMSE)评分。结果:两组患者在治疗后3和6个月的NIHSS、BI和mRS评分均比治疗前有好转,差异均有统计学意义(P<0.05)。普伐他汀联合阿司匹林治疗组在治疗后6个月时NIHSS、BI和mRS评分的好转优于单用阿司匹林治疗组,且差异均有统计学意义(P<0.05)。MMSE的变化无统计学意义。结论:普伐他汀联合阿司匹林治疗有利于神经功能、日常生活能力的恢复,改善预后,可作为急性脑梗死治疗的联合药物。Aim： To investigate the therapeutic efficacy of pravastatin combined with aspirin on the acute cerebral infarction and to improve the prognosis of the disease. Methods; 115 eases with acute cerebral infarction were randomly divided into two groups： ① 57 eases were treated with pravastatin combined with aspirin; ② 58 eases were given aspirin only. The scores of NIHSS, Barthel, mRS and MMSE were estimated before and 3 and 6 months after treatment. Results： In these two groups, all of the scores of NIHSS, Barthel and mRS were improved 3 and 6 months after the therapy （P〈0.05）. The scores of NIHSS, Barthel and mRS were more improved in pravastatin plus aspirin therapy group than those in aspirin therapy group. The significant statistical difference was found （P〈0.05）. No alternation of MMSE estimation was found with no statistical difference （P 〉0.05）. Conclusion： Pravastatin plus aspirin therapy may be beneficial of restoring the nervous function and improving the ability of daily living and the prognosis. Pravastatin plus aspirin can be used in acute cerebral infarction as a therapeutic approach.

关 键 词：普伐他汀 阿司匹林 急性脑梗死 

分 类 号：R743[医药卫生—神经病学与精神病学] R741.05[医药卫生—临床医学]