无细胞百白破疫苗加强免疫一年后的血清抗体水平  

Serum Antibody Level of Children One Year after A Booster of Acellular DTP

作　　者：肖詹蓉[1] 侯启明[2] 杨景芳[3] 李万臣[1] 项美娟[4] 梁亚文 张路民[2] 周云冲[5] 傅惠兰 凌国荣 赵金锁 陈爽[3] 李立[3] 申文生 刘德铮[1] 

机构地区：[1]北京生物制品研究所 [2]中国药品生物制品检定所 [3]长春生物制品研究所 [4]武汉生物制品研究所 [5]上海生物制品研究所 [6]成都生物制品研究所 [7]余杭市卫生防疫站

出　　处：《中国生物制品学杂志》1996年第4期180-183,共4页Chinese Journal of Biologicals

摘　　要：用无细胞百白破疫苗（DTPa）和全细胞百白破疫苗（DTPw）分别进行基础免疫，再用DTPa或DTPw加强免疫，一年后对免疫儿童进行了血清抗体检测。结果各类抗体均较加强免疫后一个月明显下降，3个组中抗—FHA虽有所下降，但均在保护水平以上（＞20EU／ml），抗—PT抗体只有DTPa组大于20EU／ml。3个组中的大多数儿童的百日咳凝集抗体均＜1：320，而抗白喉类毒素（抗—DT）、抗破伤风类毒素（抗—TT）抗体均在保护水平以上。The children immunized with acellular DTP (DTPa) or whole cell DTP (PTPw) were divided into 3 groups: (1)received the primary immunization of DTPa and a booster of DTPa; (2)received the primary immunization of DTPw and a booster of DTPw;(3)received the primary immunization of DTPw and a booster of DTPa. The serum antibody levels of the children were detected one year after the boosters had been given. The result showed that levels of all kinds of antibodies were significantly decreased in comparision with those detected one month after the boosters were given. The anti -FHA of the 3 groups were above protective level (20 EU/ml ), however, only the anti - PT of the group (1) was above 20EU/ml. The pertussis agglutlnating antibody levels of most of the childen were less than 1: 320,but the anti-DT and anti-TT of them were above protective levels.

关 键 词：无细胞百白破 疫苗 血清抗体水平 生物制品 鉴定 

分 类 号：R392－33[医药卫生—免疫学]