cyclin G1和p16蛋白在子宫平滑肌肿瘤中的表达及意义  

The expression of cyclin G1 and p16 protein in human uterine smooth muscle tumors.

作　　者：张素丽[1] 郑红兵[1] 

机构地区：[1]武汉华中科技大学同济医学院附属同济医院妇产科,湖北武汉430030

出　　处：《现代肿瘤医学》2006年第8期989-992,共4页Journal of Modern Oncology

摘　　要：目的:探讨cyc lin G1和p16蛋白在子宫平滑肌肿瘤(USMTs)中的表达及临床意义。方法:应用免疫组织化学方法检测35例良性子宫平滑肌瘤(UL),18例子宫平滑肌肉瘤(LMS)及22例交界性子宫平滑肌瘤(BLM):包括13例富于细胞型子宫平滑肌瘤(CL)、4例奇异型子宫平滑肌瘤(BL)及5例恶性潜能未定型子宫平滑肌瘤(UMP)的cyc lin G1和p16蛋白的表达。结果:cyc lin G1和p16蛋白在LMS组的阳性表达率和表达强度均显著高于UL组及BLM组(P<0.05);在UL组与BLM组,cyc lin G1和p16蛋白阳性表达率和表达强度均无明显差异(P>0.05)。结论:cyc lin G1和p16蛋白的异常表达与LMS的发生发展密切相关,细胞周期调控失衡可能是LMS的发病机制之一。Objective：To investigate the expression and the clinical significance of cyclin G1 and p16 protein in human uterine smooth muscle tumors （USMTs）. Methods： Immunohistochemical technique was used to detect the cyclin G1 and p16 protein expression in 35 usual leiomyoma （UL）, 18 leiomyosarcoma（LMS） and 22 borderline leiomyoma（BLM） ： including 13 cellular leiomyoma （CL）, 4 bizarre leiomyoma （BL）, 5 smooth muscle tumors of uncertain malignant potential （UMP）. Results： The positive rates and intensity of cyclin G1 and p16 protein expression in LMS were significantly higher than those in UL and in BLM, P〈0.05 ; But no significant difference was found between UL and BLM, P〉0.05. Conclusion： The abnormal expression of cyclin G1 and p16 protein was associated with the pathogenesis and development of LMS. The regulatory unbalance of cell cycle may be involved in the pathogenesis of LMS.

关 键 词：子宫肿瘤 CYCLIN G1 P16 

分 类 号：R737.33[医药卫生—肿瘤]